วัน: 17 ตุลาคม 2024

Johannesburg, South Africa, Oct 15, 2024 - (ACN Newswire via SeaPRwire.com) - In the rapidly evolving field of healthcare, technological advancements are continually transforming both medical education and the delivery of healthcare services. Innovative solutions, in the healthcare field, present new possibilities for enhancing learning, improving patient outcomes, and advancing medical practices. These cutting-edge methods allow students and healthcare professionals to gain a deeper understanding of complex medical concepts and sharpen essential skills. Simultaneously, they foster the growth of local industries, driving innovation and creating economic opportunities, while addressing critical healthcare needs in a more sustainable and efficient way.One such innovation is focused on revolutionising medical education and healthcare in South Africa through the application of advanced 3D printing technology. By utilising this state-of-the-art tool, students and professionals are gaining unprecedented opportunities to deepen their knowledge of human anatomy, hone their surgical skills, and enhance patient care. This not only raises the standard of education but also contributes to the growth of local manufacturing industries, promoting healthcare excellence and economic development. Moreover, it strengthens South Africa's manufacturing capabilities, particularly in the production of medical devices.This collaboration fosters innovation and empowers small and medium enterprises (SMMEs) to compete on a global scale. With a focus on customized medical solutions, the initiative supports local manufacturing, creating jobs, and building a sustainable medical device industry. By encouraging collaboration between academic institutions and businesses, the project enhances the manufacturing ecosystem and contributes to South Africa's overall economic growth while addressing vital healthcare needs.Overview of the event: 26th Edition of the South Africa Manufacturing ShowThe 26th Edition of the South Africa Manufacturing Show is part of a global series that has been held in over 10 cities across multiple continents in recent years. This exclusive, invitation-only in-person event, which will be held on November 21, 2024 in  Qurtuba Convention Centre, Johannesburg is designed specifically for technology leaders from top businesses, institutions, and government officials representing South Africa’s manufacturing sector.The agenda for the South Africa Manufacturing Show has been carefully curated to pinpoint the essential strategies required for making informed business decisions, enhancing operational efficiency, and advancing digital culture. The Summit will gather more than 200 C-Level Executives, Directors, and Heads of Technology to explore the potential of AI, Web 3.0, IoT, Cyber Security, and other Fourth Industrial Revolution (4IR) technologies, providing the insights necessary to initiate meaningful change in the industry today.Who will attendPandelani Reuben Munyai, Group CIO, Transnet SOC Ltd.Dhevan Pillay, CEO, LTM Energy Group.Oltesh Thobias, Regional Chief Procurement & Contracts Officer, African Development Bank Group.Stavros Nicolaou, Group Senior Executive, Aspen Pharmacare Holdings Ltd.The event will cover topics like:From Factory to Future: Industry 4.0's Role in South Africa's Manufacturing Evolution.From Concept to Creation: The Synergy of AI, 3D Printing, and South African Innovation in Manufacturing.Powering South Africa's Green Industrial Revolution: Balancing Sustainability, Energy Resilience, and Manufacturing Growth.Unleashing Efficiency: Harnessing Data Analytics in Manufacturing Processes.Regional Manufacturing to Achieve Health Equity and Security on the African Continent.Building Supply Chain Agility: Crafting Resilient Supply Chains in South Africa.For more information on the 26th edition South Africa Manufacturing Show, click the LinkAbout ExitoExito, which means success in Spanish, embodies our commitment to the success of our customers. Each year, we host over 240 virtual and in-person conferences globally, bringing together audiences with world-class thought leaders and C-level executives across industries. Our meticulously crafted agendas, based on extensive research and valuable industry insights, facilitate business, knowledge transfer, deal flow, and impactful messaging for brands.For Media Enquiries, contact:Kasturi Nayak (Sr. Marketing Executive)Kasturi.nayak@exito-e.comEnquiry@exito-e.comExito Media Concepts Copyright 2024 ACN Newswire via SeaPRwire.com.

Brisbane, Queensland, Australia--(ACN Newswire via SeaPRwire.com - October 16, 2024) - Graphene Manufacturing Group Ltd. (TSXV: GMG) ("GMG" or the "Company") is pleased to provide a business update on the commercialisation progress of THERMAL-XR® Powered by GMG Graphene.CUSTOMER ENGAGEMENT UPDATEGMG continues to carry out both Supply and Service Coating for various Air Conditioning Manufacturers, Distributors, Contractors and end equipment owners - including the large HVACR condensing units showing the black coating of THERMAL-XR on the condenser coils seen in Figure 1.Figure 1: GMG Team Members in front of large HVACR condensing units coated with THERMAL-XRTo view an enhanced version of this graphic, please visit:https://images.newsfilecorp.com/files/8082/226793_4a202364a43cd862_001full.jpgAt an event on 4th October 2024 in Brisbane, Australia that included the broad participation of HVAC industry representatives, GMG successfully RE-launched THERMAL-XR® ENHANCE. The focus of the event was on Thermal-XR's unique heat transfer and corrosion protection capabilities. When first developed, the product was named THERMAL-XR® RESTORE because the Company believed its principal benefit was to restore the heat transfer capabilities of existing installed air conditioners. However, GMG has since proved with third party verification that the product can also enhance the heat transfer of new equipment; hence the re-branding to THERMAL-XR® ENHANCE.As a result, GMG now believes that THERMAL-XR® ENHANCE has exciting opportunities with HVAC Original Equipment Manufacturers ("OEMs") in addition to its potential in the HVAC aftermarket. Over the past several months, GMG has completed on-site testing of THERMAL-XR® with global Air Conditioning Manufacturers in China and the USA for potential introduction into their factories. While further customer testing will be required, GMG believes early results are promising.Apart from applications in the HVAC industry, the unique heat transfer capabilities of THERMAL-XR® ENHANCE has also led to potential new applications in a wide range of industries where reducing heat is important. For example, customer managed Third Party Laboratory Testing with THERMAL-XR® is now being done with companies that operate LNG facilities; companies that manufacture electronic products; and companies that produce motors for the industrial and automotive markets. Further testing will be required to confirm the benefits of using THERMAL-XR® ENHANCE in such applications.Figure 2: RE-LAUNCH of THERMAL-XR® ENHANCETo view an enhanced version of this graphic, please visit:https://images.newsfilecorp.com/files/8082/226793_4a202364a43cd862_002full.jpgAs shown in Figure 2, THERMAL-XR® ENHANCE will now be available in 5 litre pails, instead of the original 10 litre containers. Customers have expressed their preference for lighter weight pails because they believe they are easier to lift onto roof tops for spraying in-situ air conditioners. Generally, 5 Litres of THERMAL-XR can be used to spray up to 5 small to medium size air conditioners, covering approximately 50 square metres of solid plate.As previously announced, GMG and Nu Calgon have signed an agreement and are working with a consultant to prepare and submit a Pre-Manufacture Notice ("PMN") in conjunction with its USA Environmental Protection Agency's ("EPA") application to import and sell in the USA. The PMN application is expected to be submitted before the end of October, and the approval is expected to take less than 12 months. The PMN will be substantially different from the Low Volume Exemption ("LVE") PMN that was previously submitted by GMG. Unlike the LVE PMN application that was limited to 10 tons per annum and one application technique in the HVAC sector, the PMN EPA approval that GMG is now seeking will not be limited by volume, application and any one particular sector.INDUSTRY RECOGNITIONTHERMAL-XR® is a finalist in the AIRAH Product of the Year - to be announced on 21st November 2024. AIRAH, the Australian Institute of Refrigeration, Air Conditioning and Heating, is the peak body representing the HVAC&R industry in Australia. Officially incorporated by guarantee on March 29, 1920, AIRAH celebrated its Centenary anniversary in 2020.The AIRAH Awards provide our industry with the opportunity to reflect, applaud, and raise a toast to our peers and their achievements - from promising future leaders to established sector veterans; from the finest new projects to the best retrofits; as well as the greatest in refrigeration, renewable energy, and research. Independent industry specialists determine a shortlist of finalists, from which a winner is selected by an expert judging panel. This rigorous and impartial process makes the AIRAH Awards the most highly prized accolades in Australia's HVAC&R building services industry.To view an enhanced version of this graphic, please visit:https://images.newsfilecorp.com/files/8082/226793_4a202364a43cd862_003full.jpgGMG's Managing Director and CEO, Craig Nicol, commented: "We believe GMG continues to make good progress in testing its products in large global OEM's for various types of products in various applications whilst our technical understanding of the coating improves - creating an exciting cycle of innovation and learning with our customers and how we make the graphene and coating, how it is applied and also how it is marketed and sold."GMG's Chairman and Director, Jack Perkowski, commented: "THERMAL-XR® testing in so many of these applications is very exciting to see and I am encouraged by its potential for progress in these markets."TEAM UPDATEGMG would like to thank Bobby Bran, Chief Projects Officer ("CPO"), for his near 6-year service at the Company. In the Company's continued efforts to transform into a commercial operation, the Company has decided to outsource major project activity going forward and as such will no longer need a CPO.On behalf of GMG and its Board of Directors, Craig Nicol and Jack Perkowski would like to thank Bobby for his dedication and service during his near 6-year tenure at the Company.About THERMAL-XR® powered by GMG Graphene:THERMAL-XR® COATING SYSTEM is a unique method of improving the conductivity of corroded heat exchange surfaces and improving and maintaining the performance of new units at peak levels. The process coats and protects heat exchange surfaces while improving and rebuilding the lost corroded thermal conductivity and increasing the heat transfer rate by leveraging the physics of GMG Graphene, resulting in an efficiency improvement and a potential power reduction.THERMAL-XR RESTORE® is powered by GMG Graphene. PATENT PENDINGAbout GMG www.graphenemg.comGMG is a clean-technology company which seeks to offer energy saving and energy storage solutions, enabled by graphene, including that manufactured in-house via a proprietary production process. GMG has developed a proprietary production process to decompose natural gas (i.e. methane) into its elements, carbon (as graphene), hydrogen and some residual hydrocarbon gases. This process produces high quality, low cost, scalable, 'tuneable' and low/no contaminant graphene suitable for use in clean-technology and other applications.The Company's present focus is to de-risk and develop commercial scale-up capabilities, and secure market applications. In the energy savings segment, GMG has focused on graphene enhanced heating, ventilation and air conditioning ("HVAC-R") coating (or energy-saving coating), lubricants and fluids.In the energy storage segment, GMG and the University of Queensland are working collaboratively with financial support from the Australian Government to progress R&D and commercialization of graphene aluminium-ion batteries ("G+AI Batteries").GMG's 4 critical business objectives are:Produce Graphene and improve/scale cell production processesBuild Revenue from Energy Savings ProductsDevelop Next-Generation BatteryDevelop Supply Chain, Partners & Project Execution CapabilityFor further information please contact:Craig Nicol, Chief Executive Officer & Managing Director of the Company at craig.nicol@graphenemg.com, +61 415 445 223Leo Karabelas at Focus Communications Investor Relations, leo@fcir.ca, +1 647 689 6041Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accept responsibility for the adequacy or accuracy of this news release.Cautionary Note Regarding Forward-Looking Statements This news release includes certain statements and information that may constitute forward-looking information within the meaning of applicable Canadian securities laws. Forward-looking statements relate to future events or future performance and reflect the expectations or beliefs of management of the Company regarding future events. Generally, forward-looking statements and information can be identified by the use of forward-looking terminology such as "intends", "expects" or "anticipates", or variations of such words and phrases or statements that certain actions, events or results "may", "could", "should", "would" or will "potentially" or "likely" occur. This information and these statements, referred to herein as "forward‐looking statements", are not historical facts, are made as of the date of this news release and include without limitation, the potential for THERMAL-XR® to enable energy producers to produce additional energy more efficiently, the potential for THERMAL-XR® ENHANCE to enhance the heat transfer of new equipment and its opportunities with HVAC industry and other industries where reducing heat is important, the timing of submission of the Company's PMN application, the receipt, timing and nature of approval by the EPA of the PMN application, the Company's goal of achieving optimal production line performance for THERMAL-XR® and the entering of full production. Such forward-looking statements are based on a number of assumptions of management, including, without limitation, assumptions regarding the development of extensions and enhancements to the THERMAL-XR® portfolio into a wider range of applications, that energy producers will be able to derive the expected benefits from the Company's products, that the Company's PMN application will be submitted on the timetable anticipated, that the EPA will approve the PMN application and on the timing anticipated, that the content of the EPA's approval will be as anticipated, and that the Company will be able to achieve optimal production line performance for THERMAL-XR® and enter full production. Additionally, forward-looking information involves a variety of known and unknown risks, uncertainties and other factors which may cause the actual plans, intentions, activities, results, performance or achievements of GMG to be materially different from any future plans, intentions, activities, results, performance or achievements expressed or implied by such forward-looking statements. Such risks include, without limitation: that there will be no developments of extensions or enhancements to the THERMAL-XR® portfolio into a wider range of applications, that energy producers will not derive the expected benefits from the Company's products, that the Company's PMN application will not be submitted on the timetable anticipated or at all, that the EPA will not approve the PMN application on the timing anticipated or at all, that the content of the EPA's approval will not be as anticipated, that the Company will be unable to achieve optimal production line performance for THERMAL-XR® or enter full production, risks relating to the extent and duration of the conflict in Eastern Europe and its impact on global markets, the volatility of global capital markets, political instability, the failure of the Company to obtain regulatory approvals, attract and retain skilled personnel, unexpected development and production challenges, unanticipated costs and the risk factors set out under the heading "Risk Factors" in the Company's annual information form dated October 3, 2024 available for review on the Company's profile at www.sedarplus.ca.Although management of the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. Readers are cautioned that reliance on such information may not be appropriate for other purposes. The Company does not undertake to update any forward-looking statement, forward-looking information or financial out-look that are incorporated by reference herein, except in accordance with applicable securities laws. We seek safe harbor.To view the source version of this press release, please visit https://www.newsfilecorp.com/release/226793 Copyright 2024 ACN Newswire via SeaPRwire.com.

Kincora to raise A$1.27 million (C$1.19 million) via strategic investment by Fleet Space, existing major shareholder, directors and new investors participationRaise conducted at A$0.038 (C$0.036) with 1:2 attaching option at A$0.075 (C$0.07)Fleet Space to invest A$400,000 (C$373,832) to take initial ~4% strategic stake in KincoraExpanded partnership with Fleet Space including Kincora's recently secured and wholly owned Wongarbon ProjectMultiphysics survey agreement comprising Ambient Noise Tomography (ANT) and gravity surveys with Fleet Space's end-to-end mineral exploration solution, ExosphereFleet Space has the right to fund a minimum 2,000m drill program to earn a 20% stake in the ProjectThe Wongarbon Project is interpreted to host one of the last remaining untested and large intrusive complexes of the Macquarie Arc situated on an interpreted common transverse structure that is a key control to the 14.7Moz gold equivalent inventory within Alkane Resources Limited's Northern Molong Porphyry Project (NMPP) 1Final interpretations are pending for a recent Fleet Space ANT survey at the NMPP and multiphysic surveys at the Nyngan Project ahead of imminent drill testingMelbourne, Australia--(ACN Newswire via SeaPRwire.com - October 16, 2024) - Kincora Copper Limited (TSXV: KCC) (ASX: KCC) (Kincora or the Company) is pleased to have expanded its partnership with Fleet Space Technologies Pty Ltd (Fleet Space) to include: (i) a listed equity investment, (ii) multiphysics surveys at the Wongarbon Project to identify and refine targets, and, (iii) the right to drill test targets to earn an asset level interest in the Wongarbon Project.Fleet Space is Australia's fastest growing company 2 and widely recognised as Australia's leading space exploration company. Fleet Space seeks to revolutionise mineral exploration with its vertically integrated technology stack, ExoSphere, which combines the latest advances in satellite connectivity, 3D multiphysics data acquisition and AI to map mineral systems in real-time to streamline exploration and improve success rates for new economic discoveries.The Wongarbon Project has never been drilled, is located in the interpreted extension of the Northern Molong Belt of the Macquarie Arc, NSW, and is considered to be highly prospective for a new large-scale porphyry copper-gold complex and series of discoveries.Sam Spring, President and CEO of Kincora, commented: "Kincora and Fleet Space strongly believe the Wongarbon Project has the potential to be a new porphyry district and it is a prime candidate for major discovery. We are very pleased to have entered this innovative and multiple phase agreement. The results of our recent multiphysics surveys at our Nyngan Project are pending and the structure of this expanded partnership with Fleet Space provides unique alignment. We look forward to shortly advancing the first new exploration at the Wongarbon Project in almost 30-years with a pathway for refining and drilling true and large-scale virgin targets. This is Kincora's fifth recent partnership further demonstrating how we work with technical partners to apply industry leading exploration techniques to systematically advance, fund and de-risk our project pipeline of highly prospective porphyry targets. Further deals and partnerships are proposed for other Kincora projects and we thank existing shareholders for their support in the capital raising and welcome some good new groups to the register."Fleet Space Director, CFO and Financial Strategy & Investment Officer, Federico Tata-Nardini, said:"In a major advance for exploration in the Macquarie Arc, we are excited to deploy Fleet Space's proprietary ExoSphere technology stack and multiphysics surveys at the Wongarbon Project, building upon our relationship with Kincora. These agreements reflect a complete end-to-end deployment of ExoSphere, from target generation to drill testing on a project that offers new district scale potential and has never been drilled. Fleet Space has invested very significantly in the Macquarie Arc and established a unique knowledge of a number of the key porphyry systems and emerging discoveries. We have completed five surveys, including recently at the Boda-Kaiser deposits. Why Because we believe there are further Cadia-scale deposits to be found and that our Exosphere technology will play a fundamental role in uncovering the next one as we continue to enhance mineral systems knowledge worldwide.Wongarbon's geological and geophysical setting is favourably located in a highly prospective area of the Arc. It has clear analogues of the nearby porphyry complexes and existing Tier 1 deposits. We believe the project is at the stage where we can add significant value and mutually share major discovery potential with Kincora."Capital Raising In conjunction with these agreements with Fleet Space, the Company is pleased to announce that it has received binding commitments for a two tranche share placement comprising 33.5m shares at an issue price of $0.038 (C$0.036) per share to raise A$1.27m (C$1.19m) (before costs) with 1:2 attaching option at A$0.075 (C$0.07) with a 2-year term (the "Placement"). The issue price is a 12% discount to the last close price (October 10th, 2024) and 16% discount to the 15 day VWAP (on the ASX).The Offering has been led by strategic investments for A$400,000 (C$373,832) by Fleet Space's investment fund, a new arms-length investor, and Big Ben Holdings, a long-term shareholder of Kincora's maintaining its 12.9% stake.Allotment of tranche 1 of the Placement to professional and sophisticated investors will take place on October 22nd, 2024, with 12.6m shares being issued under Kincora's Listing Rule 7.1 placement capacity. Tranche 2 of the Placement (comprising 20.9m shares and 16.8m attaching options) will be subject to shareholder approval pursuant to a General Meeting, with further details to be provided to shareholders in a Notice of Meeting to be lodged shortly.Subject to shareholder approval, Directors intend to purchase C$50,000 of shares under tranche 2 of the Placement with Fleet Space and Big Ben Holdings also agreeing to participate in tranche 2. Fleet Space has agreed to a 12-month voluntary escrow period.Morgans Corporate Limited acted as Lead Manager to the Placement. A cash transaction cost of 3.9% of the Placement is payable.In addition to the Placement, the Company will issue 11m accrued remuneration shares to Kincora's board and senior management under the Equity Incentive Plan approved by shareholders.Post the proposed issuances, Kincora's total outstanding number of fully issued shared is anticipated to be 291.7m with 69m total options outstanding.Use of FundsThe funds used from the Placement is intended to support:(i) drilling and exploration at the Condobolin Project;(ii) Ambient Noise Tomography (ANT) and gravity surveys at the Wongarbon Project with target refinement ahead of Fleet Space's right to drill a minimum of 2000 metres to earn a 20% stake in the Project; and,(iii) offering costs, working capital, new direct application license acquisition and general project generation opportunities.The New Partnership Fleet Space and Kincora have entered an agreement to commence multiphysics surveys at the Wongarbon Project with a path to asset level partnership:1) Fleet Space will have a right to fund a minimum of 2,000m drill program, with drill targets:identified and refined from the multiphysics surveys using Fleet Space's ExoSphere Discovery technology; and,mutually agreed by Kincora and Fleet Space.2) An exercise of the right in 1) will entitle Fleet Space to a 20% equity interest in the Wongarbon Project.3) The right in 1) may be exercised within 6 months of the completion of the multiphysics surveys.4) Should Fleet Space exercise the right, the parties will enter into a Joint Venture Agreement (JV Agreement). Key principles governing the JV Agreement will be customary for such stage exploration project including both parties having the right to provide additional funding maintain their respective ownership interests and dilution provisions should either party not participate in additional project funding, noting that any holder of a project interest less than 10% will have its interest converted to a 1% Net Smelter Return (NSR) royalty.Fleet Space is to be the operator of the multiphysics surveys, with support from Kincora, and Kincora the operator of the drilling program.The multiphysics surveys will comprise real-time 3D Ambient Noise Tomography (ANT) and ground gravity surveys applying industry leading technology to generate and interpret new homogeneous and primary datasets via Fleet Space's proprietary and vertically integrated technology stack, ExoSphere, and be integrated with existing regional geophysical surveys and geological data.While interpretations are ongoing by Kincora, Fleet Space and AngloGold Ashanti the multiphysics surveys have confirmed and refined a regionally significant priority target ahead of imminent drilling. The surveys have also generated a number of previously unrecognised areas of interest and potential new target areas with a final review to integrate the results of the commenced drilling program results in conjunction with AngloGold Ashanti.About the Wongarbon ProjectPegged as open ground and secured only in June 2024, the Wongarbon project (EL9652) covers 173km2 and is interpreted to host one of the last remaining untested and large intrusive complexes of the Macquarie Arc:Regionally significant magmatic complex situated on the interpreted under cover extension of the northern Molong Belt coincident with an intrusive level cross arc structure supporting a series of large and untested porphyry targets.Clear analogues of the nearby complexes and existing Tier 1 deposits in the Arc and aeromagnetic signatures of other globally significant porphyry deposits.Previously identified as a large-scale new intrusive complex target by Newcrest but not drill tested at the time due to focus on the Cadia Far East and Ridgeway discoveries.Recent interpretations support immediate high priority targets for drilling.The Wongarbon project has never been drilled.Alkane and Magmatic Resources' have recently undertaken drilling at a total of seven porphyry targets along a common transverse structure that is interpreted to extend into the Wongarbon Project and be a key control to the 14.7Moz gold equivalent inventory at the Boda and Kaiser porphyry deposits 1. These recent programs have been encouraging with follow up exploration either planned and/or ongoing at these and other regional targets 3.Fleet Space has recently undertaken regional and infill ANT surveys at Alkane's Northern Molong Porphyry Project (NMPP), including the Boda and Kaiser deposits, with analysis and interpretation ongoing. Similar Fleet Space surveys across the Macquarie Arc, including Kincora's Nyngan Project, are noted as having refined and generated multiple new porphyry targets.Further details on the Wongarbon Project, including a detailed project level presentation, are available at: https://kincoracopper.com/wongarbon-project/ (Projects/Wongarbon).Further details on Kincora's wholly owned, district scale project portfolio and drill ready copper-gold porphyry projects are available on the Company's website: https://kincoracopper.com.About Fleet Space Technologies Fleet Space is private and widely recognised as Australia's leading space exploration company. Fleet Space seeks to revolutionise mineral exploration with its vertically integrated technology stack, ExoSphere, which combines the latest advances in satellite connectivity, 3D multiphysics data acquisition, and AI to map mineral systems in real-time.Fleet Space's ExoSphere technology enables an end-to-end approach to high-quality data acquisition, processing, interpretation and targeting to streamline exploration and improve success rates for new economic discoveries.Leveraging Fleet Space's proprietary satellite network in low Earth orbit, smart seismic sensors enabled with edge computing and rapid data processing, ExoSphere delivers real-time 3D mapping of mineral systems and AI-powered drill targeting with near-zero environmental impact.In the last quarter, Barrick Gold announced it would partner with Fleet Space to survey copper porphyry complexes across 1,150km² of the world-class Reko Diq project 4 and in the last month Gold Fields announced a similar relationship to advance exploration at the Salares Norte project in Chile 5.Recently, Inflection Resources' announced new targets generated by ExoSphere, leading AngloGold to accelerate their Exploration Agreement and drilling with Inflection 5. Inflection and Fleet Space have also recently announced the results of the world's largest real-time ANT survey across 1818km², built an AI-powered district scale copper prospectivity map which, when integrated with other existing datasets (including airborne magnetics and gravity), has resulted in four new priority targets, three of which are within 2km's of Kincora wider project portfolio in the northern Junee-Narromine Belt 6.ExoSphere's rapid global adoption has propelled Fleet Space's exponential growth, including a A$50 million Series C funding round, a doubling of its valuation to A$350 million, plans to send a variant of ExoSphere to the Moon in 2026, and recognition as Australia's fastest growing company 2.For more information please visit Fleet Space's website at https://www.fleetspace.com.About Kincora Kincora Copper is dual listed on the ASX and TSX-V (ticker "KCC") and is an active explorer and project generator focused on world-class copper-gold discoveries that has recently executed five agreements that unlock up to >A$60 million in multiple year partner funding. Further new projects that offer a clear value path and targeted partnerships are proposed.Kincora's portfolio includes district scale landholdings and scale-able drill ready targets in both Australia and Mongolia's leading porphyry belts, the Macquarie Arc and Southern Gobi, respectively, and, the Company is targeting exposure to 10,000-30,000m pa of drilling.For more information please visit Kincora's website at www.kincoracopper.comReferences:(1) Annual Resources & Reserves Statement FY24 - Alkane Resources Limited (ticker ALK.ASX) release September 4, 2024(2) According to the Australian Financial Review (2023)(3) 2Q'2024 Quarterly Activities Reports - Alkane Resources Limited and Magmatic Resources Limited (ticker MAG.ASX)(4) ANT geophysics defines additional epithermal-porphyry targets at Spur Project - Waratah press release May 23, 2024(5) Reimaging porphyry copper exploration using Exosphere: Ambient Noise Tomography from the Duck Creek project, Macquarie - Fleet and Inflection Case Study 2023 (6) Completes 1,800Km2 Ambient Noise Tomography Survey Across Portfolio of Projects in New South Wales - Inflection press release July 10, 2024(7) Fleet Space's Exosphere Enhances Barrick Gold's Data-Driven Copper Exploration at Reko Diq - Fleet Space press release July 9, 2024(8) Gold Fields Taps ExoSphere To Advance Exploration at Salares Norte in Chile - Fleet Space release October 3, 2024(9) Inflection Resources Defines New Priority Targets Based on Results of Regional ANT Survey in New South Wales - Inflection press release September 12, 2024This announcement has been authorised for release by the Board of Kincora Copper Limited (ARBN 645 457 763)For further information please contact: Sam Spring, President and Chief Executive Officer sam.spring@kincoracopper.com or +61 431 329 345Executive office400 - 837 West Hastings Street Vancouver, BC V6C 3N6, CanadaTel: 1.604.283.1722 Fax: 1.888.241.5996Subsidiary office Australia Vista Australia Level 4, 100 Albert RoadSouth Melbourne, Victoria 3205Qualified Person The scientific and technical information in this announcement was prepared in accordance with the standards of the Canadian Institute of Mining, Metallurgy and Petroleum and National Instrument 43-101 - Standards of Disclosure for Mineral Projects ("NI 43-101") and was reviewed, verified and compiled by Kincora's staff under the supervision of Peter Leaman (M.Sc. Mineral Exploration, FAusIMM), Senior Vice-President of Exploration of Kincora, and John Holliday (BSc Hons, BEc, member of the Australian Institute of Geoscientists), Non-Executive Director and Chairman of Kincora's Technical Committee, who are Qualified Person(s) for the purpose of NI 43-101.JORC Competent Person StatementInformation in this announcement that relates to Exploration Results, Mineral Resources or Ore Reserves are those that have been previously reported (with the original release referred to in this announcement) and the Company is not aware of any new information or data which materially affect the information included in those prior reports and, in the case of Mineral Resources or Ore Reserves the material assumptions and technical parameters underpinning the estimates have not materially changed, and have been reviewed and approved by John Holliday and Peter Leaman, who are Competent Person(s) under the definition established by JORC and has sufficient experience which is relevant to the style of mineralisation and type of deposit under consideration and to the activity being undertaking to qualify as a Competent Person as defined in the 2012 Edition of the 'Australasian Code for Reporting of Exploration Results, Mineral Resources and Ore Reserves'. John Holliday and Peter Leaman consent to the inclusion in this report of the matters based on the information in the form and context in which it appears. The review and verification process for the information disclosed herein for Kincora's projects have included the receipt of all material exploration data, results and sampling procedures of previous operators and review of such information by Kincora's geological staff using standard verification procedures.Forward-Looking StatementsCertain information regarding Kincora contained herein may constitute forward-looking statements within the meaning of applicable securities laws. Forward-looking statements may include estimates, plans, expectations, opinions, forecasts, projections, guidance or other statements that are not statements of fact. Although Kincora believes that the expectations reflected in such forward-looking statements are reasonable, it can give no assurance that such expectations will prove to have been correct. Kincora cautions that actual performance will be affected by a number of factors, most of which are beyond its control, and that future events and results may vary substantially from what Kincora currently foresees. Factors that could cause actual results to differ materially from those in forward-looking statements include market prices, exploitation and exploration results, continued availability of capital and financing and general economic, market or business conditions. The forward-looking statements are expressly qualified in their entirety by this cautionary statement. The information contained herein is stated as of the current date and is subject to change after that date. Kincora does not assume the obligation to revise or update these forward-looking statements, except as may be required under applicable securities laws.Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) or the Australian Securities Exchange accepts responsibility for the adequacy or accuracy of this release.To view the source version of this press release, please visit https://www.newsfilecorp.com/release/226763 Copyright 2024 ACN Newswire via SeaPRwire.com.

- The two major electronics fairs concluded today, attracting over 60,000 industry buyers from 136 countries and regions- 53% of respondents in an on-site survey expect overall sales to increase over the next 12-24 months, while 43% expect sales to remain stable- Most respondents believe there is a “very promising” or “promising” market potential for wearable electronic products (65%) and robotics technology (59%)HONG KONG, Oct 16, 2024 - (ACN Newswire via SeaPRwire.com) - The Hong Kong Electronics Fair (Autumn Edition), organised by the Hong Kong Trade Development Council (HKTDC), and electronicAsia, jointly organised by the HKTDC and MMI Asia Pte Ltd, concluded their physical exhibitions today.The four-day events attracted more than 60,000 industry buyers from 136 countries and regions. The number of buyers from Malaysia, Türkiye, Argentina and the UAE increased from last year. This reflects the exhibitions' status as important sourcing platforms for the industry.Sophia Chong, Deputy Executive Director of the HKTDC, said: "The global trend towards smart living is driving demand for innovative products and solutions. The Electronics Fair and electronicAsia serve as efficient platforms for the industry, enabling exhibitors to showcase their electronic products and technology solutions to buyers. We are pleased to see exhibitors and buyers successfully exploring business opportunities at the exhibitions, which are expediting Hong Kong's development into an international innovation and technology (I&T) centre.”In late October, the HKTDC will host the Hong Kong International Lighting Fair (Autumn Edition), Hong Kong International Outdoor and Tech Light Expo and ECO Expo Asia to create more cross-industry business opportunities.Industry optimistic about India, the Middle East, Latin AmericaAn independent survey agency commissioned by the HKTDC interviewed 1,091 Electronics Fair buyers and exhibitors about growth prospects for the industry. 53% of respondents expect overall sales to increase in the next 12-24 months, while 43% anticipate that they will remain stable. Most respondents believe that the electronics industry has the most growth potential in emerging markets, such as India, the Middle East and Latin America over the next two years, followed by Korea, Mainland China, Australia and the Pacific Islands.In terms of trends in electronic products, most respondents believe there is a “very promising” or “promising” market potential for wearable electronic products (65%) and robotics technology (59%).Meanwhile, 56% of respondents believe that the market potential for e-sports products and equipment is high. Most respondents consider these products to have the greatest growth potential in North America and Northern and Western Europe.Exhibitors attract quality buyers at fairsThis year's Electronics Fair featured more than 20 zones, gathering the latest electronic products and innovative solutions from global exhibitors in areas such as smart cities, smart mobility, gerontechnology and digital entertainment.First-time exhibitor and Founder of Zunosaki Limited, Newmen Ho, promoted the company's hand rehabilitation robot in the Startup Zone, seeking Mainland China and overseas distributors, partners and investors. In the first half of the exhibition, he met potential buyers from Taiwan’s nursing homes and from Korea. Additionally, a buyer from India expressed interest in applying the company's robotic hand technology across different industries.Hong Kong's renowned consumer electronics brand Momax achieved impressive results at the fair. The company's Founder and CEO John Cheng stated that in the first two days of the Fair, the team met some 60 buyers from the Asia-Pacific region and Europe. Momax also formed a long-term partnership with a publicly listed company in Papua New Guinea and is currently discussing an initial order valued at US$50,000.Additionally, through HKTDC’s Click2Match smart business matching platform, the company connected with another quality buyer from Australia, with the intent to collaborate long-term. Mr Cheng said: "Hong Kong's exhibitions are world-class, featuring high-quality buyers from a diverse range of countries. This year's Autumn Electronics Fair saw a significant turnout, and the buyers were very engaged. We will definitely participate again next year."Dongguan Maochang Printed Circuit Board Ltd, which develops technological solutions, participated in electronicAsia to stay updated on industry trends and identify potential buyers. The company's Sales Director, Michael Tsang, said: "Expanding onto the international stage is our primary goal for participating in the exhibition. I am glad that we met with over 200 potential buyers in the first three days to gain a deeper understanding of customer needs."Buyer seeks new products to expand marketVinal Patel, Chief Commercial Officer of UK buyer Brand Collective, has been attending the Electronics Fair for over 20 years. During the first two days of this year's fair, he secured over US$2 million worth of purchases, including charging cables, power banks and wireless speakers from two exhibitors. He is also considering expanding the range of products he distributes after discovering new offerings at the Fair. Mr Patel said: "The line-up at the exhibition gets better every year, even more impressive than before the pandemic. I will definitely participate in the Electronics Fairs in April and October in the future."Turkish buyer and Co-founder of Robotistan Elektronik Tic AS, Yusuf Gündogdu, visited electronicAsia with a purchasing budget of around U$100,000-200,000 for electronic products. He said: "The Electronics Fair is the best opportunity for me to interact face-to-face with exhibitors from around the world. I always find the best prices here. Meeting the founders of start-ups in the Startup Zone excites me. These companies are poised to become some of the best in the future and will drive market development through innovation, which I eagerly look forward to."The organisers held 78 events and forums during the exhibitions, inviting industry leaders to share unique insights and the latest industry information. These events included the Symposium on Innovation & Technology, Hong Kong Electronic Forum and Reliability Assurance for Electronic Systems Forum. Other on-site activities catered to start-ups, including investment matching, the Hong Kong Value Creation for Technology: Pitching Competition, Meet the Mentors sessions and Start-up Smart Launch.Under the EXHIBITION+ hybrid model, exhibitors and buyers can use the Click2Match smart business matching platform to conduct online meetings, in addition to attending the physical fair. Exhibitors and buyers can still explore business opportunities and conduct online negotiations through Click2Match until 23 October.Photo Download:https://bit.ly/3BVmX2RHong Kong Electronics Fair (Autumn Edition) and electronicAsia successfully concluded. The four-day events attracted over 60,000 buyers from 136 countries and regionsThis year's Symposium on Innovation & Technology, themed 'When Two Worlds Collide: The Confluence of Digital Twins & Real-Life Applications', featured heavyweight guests and attracted numerous industry professionalsThe Hall of Fame gathered consumer electronic products from renowned brands worldwide. Among them, Asia Kingston (HK) Limited, specialising in brand licensing, presented a gaming chair featuring the NASA logoLocal brands, including well-known electronic brand Momax, promoted their products to global buyersThe Tech Hall showcased products using a variety of cutting-edge technologies, including 3D printing, Internet of Things, robotics, AR and XRThis year's Electronics Fair introduced a Digital Entertainment Experience Zone, where buyers could try and explore products on-siteThe concurrent electronicAsia featured multiple zones, exhibiting products, such as electronic components and parts, keyboards and switches, power supply equipment and moreThe Hong Kong Electronic Forum, co-organised by the HKTDC, MMI Asia Pte Ltd and the Hong Kong Electronic Industries Association, was themed “Innovation Unleashed: The Intersection of Microelectronics, AI, and Open-Source Ecosystems”WebsitesHong Kong Electronics Fair (Autumn Edition):  hkelectronicsfairae/enelectronicAsia: electronicasia/enMedia enquiriesPlease contact the HKTDC’s Communications & Public Affairs Department:Katy WongTel: (852) 2584 4524Email: katy.ky.wong@hktdc.orgSnowy ChanTel: (852) 2584 4525Email: snowy.sn.chan@hktdc.orgHKTDC Media Room: https://mediaroom.hktdc.com/enAbout the HKTDCThe Hong Kong Trade Development Council (HKTDC) is a statutory body established in 1966 to promote, assist and develop Hong Kong ’s trade. With 50 offices globally, including 13 in Mainland China, the HKTDC promotes Hong Kong as a two-way global investment and business hub. The HKTDC organises international exhibitions, conferences and business missions to create business opportunities for companies, particularly SMEs, in the mainland and international markets. The HKTDC also provides up-to-date market insights and product information via trade publications, research reports and digital news channels. For more information, please visit: www.hktdc.com/aboutus. Copyright 2024 ACN Newswire via SeaPRwire.com.

HONG KONG, Oct 16, 2024 - (ACN Newswire via SeaPRwire.com) - The Hong Kong Trade Development Council (HKTDC) welcomes the 2024 Policy Address, delivered today by the Hong Kong Special Administrative Region’s (HKSAR) Chief Executive John Lee.The Policy Address presents a comprehensive set of measures, ranging from the economy and trade and people’s livelihood to high-calibre talent attraction and youth development. Leveraging Hong Kong’s one country, two systems advantages, the policies will fuel the city’s continued economic growth.Dr Peter K N Lam, Chairman of the HKTDC, said: “The Policy Address highlights the Hong Kong SAR Government’s efforts in seeking innovation and change, while striving for excellence. It addresses a wide range of areas covering economic growth, trade and investment, SME support, culture and creative as well as construction and planning. Riding on Hong Kong’s eight centre advantages, the Policy Address promotes new quality productive forces and high-quality economic development.”The annual address announced various measures to reinforce the city’s status as an international financial, shipping and trading centre. Dr Lam believed the move echoes the 20th Central Committee’s Third Plenary Session’s Resolution to develop Hong Kong into a supply chain service centre: “The HKTDC will continue to proactively promote Hong Kong’s eight centre advantages and enhance the development of high value-added supply chain services. We will step up cooperation with InvestHK to set up a mechanism and enhance the interface for attracting mainland enterprises to establish their international or regional headquarters in Hong Kong and provide one-stop diversified professional advisory services to help them go global via the Hong Kong platform.”He added that the HKTDC will strengthen advisory services of its Transformation Sandbox (T-box) programme to cover a wider range of areas and support Hong Kong enterprises as well as mainland companies in Hong Kong in regard to business transformation, sustainable development and operational upgrade. Businesses are encouraged to leverage the HKTDC’s trade platforms and events to go global and explore international market opportunities, especially in the high-potential ASEAN region.Dr Lam welcomed the HKSAR Government’s SME support measures, including the relaunch of the Principal Moratorium scheme, a HK$1 billion injection into the BUD Fund and an additional HK$500 million provision for the Incentive Scheme for Recurrent Exhibitions 2.0. He believes the measures will foster SMEs’ sustainable development and reinforce Hong Kong’s role as a leading convention and exhibition hub.The Policy Address stated the Hong Kong Shopping Festival will be relaunched in the next two years to help SMEs tap into the mainland e-commerce sales market. Dr Lam said: “The inaugural Hong Kong Shopping Festival organised by the HKTDC in August this year received an enthusiastic response. Not only did it raise participants’ brand exposure, but also provided them with practical experience in e-commerce operations. We will build on this year’s success and host the second edition of the Festival next August, and in the ASEAN market in due course, to enable Hong Kong SMEs to explore market opportunities via e-commerce and social media platforms.”To help SMEs understand e-commerce marketing, the HKTDC will publish research reports and analyses on e-commerce ecosystems in different markets, such as ASEAN, to help businesses lay a solid foundation in e-commerce operations. Through its Digital Academy and Design Gallery’s (DG) cross-border e-commerce shops on Taobao and JD International, the HKTDC has been offering comprehensive support to Hong Kong SMEs to leverage diverse e-commerce and digital marketing channels to explore mainland opportunities. DG’s 70 physical sales network in the mainland serve as an ideal platform to promote Hong Kong brands in the region. As for the ASEAN market, the HKTDC’s DG Studio programme helps connect local businesses with ASEAN physical retailers and e-commerce platforms.In terms of strengthening SMEs’ brand development, the HKTDC will continue to organise some 40 international exhibitions and conferences in Hong Kong every year. We will also set up more Hong Kong Pavilions in mainland and overseas exhibitions and further enhance business matching, to support SMEs in developing their brand and tapping global opportunities.On promotion of Hong Kong's cultural and creative industries, as mentioned in the Policy Address, more Hong Kong, mainland and overseas cultural and creative products will be added to the Asia IP Exchange (AsiaIPEX), managed by the HKTDC, to facilitate cross-sector exchanges and cooperation and contribute to Hong Kong’s development into a regional IP trading centre. Currently, the platform displays more than 28,000 IP projects available for trading. The HKTDC will continue to promote cultural and creative products as well as IP transformation and trading on its platforms, such as the Business of IP Asia Forum, Hong Kong International Licensing Show and the Hong Kong International Film and TV Market.Dr Lam also welcomed measures addressing new quality productive forces, the Northern Metropolis, digital economy and silver economy, which will help Hong Kong businesses further explore opportunities in the Guangdong-Hong Kong-Macao Greater Bay Area and Belt and Road countries and regions.Addressing the reduction of the liquor duty rate, Dr Lam believes that the move will strengthen related trade and further promote Hong Kong as a regional wine trading hub. He added that the 16th Hong Kong International Wine and Spirits Fair will be held from 7 to 9 November, which will showcase fine wines from around the world, including liquors and white wines in the mainland pavilions, whiskeys from Japan and Ireland and spirits from around the world. Fair seminars will highlight the prospects of Hong Kong’s spirits market, while Chinese liquor promotional events will help the industry seize new opportunities.In conclusion, Dr Lam said: "The HKTDC will continue to support and complement national development and the Hong Kong SAR Government's policies. We will work closely with the business community to leverage Hong Kong's advantages and promote sustainable economic growth."Media enquiriesPlease contact the HKTDC’s Communication & Public Affairs Department:Sam HoTel: (852) 2584 4589Email: sam.sy.ho@hktdc.orgTo view press releases in Chinese, please visit http://mediaroom.hktdc.com/tcAbout HKTDC The Hong Kong Trade Development Council (HKTDC) is a statutory body established in 1966 to promote, assist and develop Hong Kong's trade. With 50 offices globally, including 13 in Mainland China, the HKTDC promotes Hong Kong as a two-way global investment and business hub. The HKTDC organises international exhibitions, conferences and business missions to create business opportunities for companies, particularly small and medium-sized enterprises (SMEs), in the mainland and international markets. The HKTDC also provides up-to-date market insights and product information via trade publications, research reports and digital news channels. For more information, please visit: www.hktdc.com/aboutus.  Copyright 2024 ACN Newswire via SeaPRwire.com.

- Eng Kong is the first depot in Singapore to trial and customised this technology, after several locations such as Korea's HMM PSA New-port Terminal in Busan who has also adopted similar technology.- The Singapore version is environmentally friendly as it will address carbon emissions, carbon footprint and reduce air pollution due to paperless processing.- Significant productivity, safety and manpower advantages with process times halved. Drivers can remain in their vehicles while streamlining the depot administration process.- Eng Kong plans to expand the system to its other Singapore depots by 1Q2025, potentially boosting efficiency and boosting throughput.SINGAPORE, Oct 17, 2024 - (ACN Newswire via SeaPRwire.com) - EKH Pte Ltd. (“Eng Kong” or the “Company”, and together with its subsidiaries, the “Group”), one of Asia-Pacific’s largest shipping container depot operators, has installed and customised Singapore’s first automated container seal dispenser systems to fit their depot’s Container Management Systems (CMS) systems.The Group intends to expand the system to its other three Singapore depots by 1Q2025 and eventually its mega depot 3Q2026. Eng Kong’s mega depot, spanning 80,000 square metres, will be Singapore’s largest depot. The system will have significant productivity, safety and manpower advantages compared to traditional methods.Container seals are required to prevent theft and unauthorized access to the container contents. Previously, the seal collection process was highly manual, administrative and time-consuming, taking an average of 30 minutes before drivers could obtain seals.Eng Kong's wholly owned subsidiary, Eng Kong Container Agencies Pte Ltd, has installed and customised Singapore’s first fully automated seal dispenser system which has helped cut collection time by half. The system is fully localized for Eng Kong’s depots, ensuring seamless integration with their current logistics infrastructure.Drivers now follow a seamless and safer flow, and no longer need to disembark their vehicles - much like a drive through. Upon entering the depot, time-consuming procedures are now eased up with the use Automated Gate Registration, Acceptance and Payment Functions with the use of Depot Appointment Information and Licensed Plate Recognition (LTR) Licensed Plate Recognition (LPR) technology and a cashless payment system. The driver then collects and quality-checks the container and seals at the automated seal dispenser.Labour shortage pressures could be further eased through automation, drivers will be able to transport more containers, and administrative staff could be trained for more strategic positions.In Singapore, a total of 39.01 million TEUs were processed in 2023(1). At Eng Kong’s domestic depots, the introduction of automated seal dispensers is expected to significantly boost efficiency. As each minute saved per container adds up significantly, it has been estimated that this new initiative can save up to an estimated 50,000 of man-hours per annum for the entire process from the time the driver arrives, processing, mounting the containers and collecting the seal from the dispenser machine near the entrance. These time savings will enable for reskilling the staff to other job opportunities, enhancing workforce capabilities and booth the driver(s) earning, while increase efficiency.Additionally, Singapore’s handling capacity is expected to double once the PSA Tuas Port is completed in 2040(2). Traffic congestion around busy depots will be eased and safety for drivers improved as they no longer alight their vehicles. Labour shortage pressures could be further eased through automation, drivers will be able to transport more containers, and administrative staff could be trained for more strategic positions.Paul Ng, Co-Chairman of Eng Kong said, “As one of Singapore’s largest depot operators, we are committed to improving operational efficiency, reducing manual labour dependency and improving the safety of our depots. As Singapore’s depots transition to Tuas, which is set to be the world’s largest automated port, investing in automated solutions will allow Eng Kong to remain at the forefront of this digital transformation. The world is watching Singapore and depot operators have a role to play in embracing technology and integrating advanced solutions, driving progress across the industry.”(1) S’pore port handled record 39.01 million shipping containers in 2023, Straits Times, 13 Jan 2024(2) World’s largest automated terminal: PSA Tuas Port pioneering automation transformation with event-driven architecture, Seatrade Maritime News, 14 Feb 2024About Eng KongFounded in 1975, Eng Kong is an integrated logistics operator and a key provider of container related services to global firms operating in the Asia-Pacific region. In 1986, Eng Kong broadened its business portfolio to become regional player. Eng Kong operates 20 fully integrated container depots spanning across Singapore, China, Malaysia, Hong Kong, Thailand, and Vietnam, totalling 705,100 sq. meters.Eng Kong provides comprehensive depot related services such as storage and handling, repair and maintenance, and new build container inspection and survey. Transportation. Over the years, we have established a sound reputation for reliable, cost-efficient service.For more information, please visit https://www.engkong.com.                            Issued for and on behalf of EKH Pte. Ltd.By Financial PRFor more information, please contact:Kamal SAMUEL / LEE Ke Wei E-mail: kamal@financialpr.com.sg / kewei@financialpr.com.sgTel: +64 6438 2990 Copyright 2024 ACN Newswire via SeaPRwire.com.

ATH-063 significantly increased the number of circulating regulatory T cells (Tregs) across all doses and demonstrated enrichment in six well-described genes related to induced Treg anti-inflammatory activitiesNo serious adverse effects or dose limiting toxicities were observed at any dose level, and ATH-063 demonstrated favorable pharmacokinetics (PK) The data provides clinical verification for Athos’ Proprietary AI2 (Artificial Intelligence for Autoimmune drug development) computational software platform which generated ATH-063LOS ANGELES, CA, Oct 17, 2024 - (ACN Newswire via SeaPRwire.com) - Athos Therapeutics, Inc. ("Athos"), a clinical stage biotechnology company pioneering the development of precision small molecule therapeutics for patients with immune-mediated diseases, today announced topline results for the company's Phase 1 clinical trial of ATH-063, an investigational oral small molecule G9A inhibitor and the company's lead asset in development for the treatment of inflammatory bowel disease (IBD).The clinical trial was a randomized, double-blind, placebo-controlled study in healthy volunteers designed to evaluate safety and PK as well as provide pharmacodynamic (PD) data to provide confirmation of ATH-063's proposed mechanism of action. The trial was conducted as sequential single ascending dose (SAD) (n=32) and multiple ascending dose (MAD) (n=32) arms, and a separate food-effect (FE) (n=12) arm. Four doses (25, 75, 150, and 250 mg) of ATH-063 were administered orally.PD data showed ATH-063 selective expansion and activation of Tregs, consistent with predictions made by Athos' AI2 platform:Statistically significant increases (p<0.001) in the number of blood Tregs were observed at all ATH-063 dose levels compared to placebo subjects, and demonstrated correlation between ATH-063 blood levels and number of TregsBlood ATH-063 concentration positively correlated with increase in multiple key biomarkers of Treg activity, including strong correlation with FOXP3 (p=0.003)Induced Tregs demonstrated enrichment of six well-described genes related to Treg anti-inflammatory activitiesSTAT5A, a key signaling molecule related to induced Tregs, was activated in all cohorts and doses (p=0.0003)PD data demonstrated correlation with key biomarkers of IBD disease activity, supporting further development of ATH-063 as a treatment for IBD:Blood ATH-063 concentration correlated (p=0.012)with reduction of OSM, a well-established biomarker related to TNFA resistanceBlood ATH-063 concentration correlated with reduction of calprotectin monomers, which is an established biomarker for IBDATH-063 was well tolerated across all dose groups: No serious adverse effect or dose limiting toxicities were observed at any dose levelRobust PK results and dose proportional increases in blood levels: ATH-063 showed favorable PK results with dose-proportional increases in blood ATH-063 concentrations throughout the study"The results of our first-in-human clinical trial of ATH-063 exceeded our high expectations," said Dimitrios Iliopoulos, PhD, MBA, Founder, President & CEO, Athos. "We used the Athos AI2 drug development platform to identify a previously unrecognized and novel therapeutic target, to create ATH-063, and to preclinically predict the compound's proposed mechanisms of action. We are delighted that these Phase 1 results serve as clinical verification for the predictions made by the Athos AI2 computational engine" added Dr. Iliopoulos."Our Phase 1 data showed that once daily, oral dosing of ATH-063 was well tolerated and showed expansion of Tregs," commented Allan Pantuck, MD, MS, FACS, Chairman, Founder & CMO. "We are excited to move to our next stage of clinical development in subjects with moderately to severely active ulcerative colitis. The rapid pace of the ATH-063 program, from initial target identification to a completed Phase 1 trial, was enabled by the use of our innovative approach to leveraging Artificial Intelligence for drug development."About ATH-063ATH-063 is a novel, investigational, AI-generated, oral, small molecule, G9A inhibitor in development for the treatment of inflammatory bowel disease and other autoimmune diseases. G9A is a central hub on a gene network that was identified by the Athos AI2 platform through the integration of multi-omic and longitudinal clinical data from Athos' IBD biorepository. ATH-063 is designed to directly target G9A enzymatic activity in human CD4 T cells and GI epithelial cells, acting both by suppressing pro-inflammatory responses through expansion and activation of regulatory T cells and inducing direct mucosal healing through regulation of tight junction proteins.About Athos TherapeuticsAthos Therapeutics is a clinical stage biotechnology company seeking to develop potential first-in-class therapeutics that significantly impact the lives of patients with autoimmune disorders and chronic inflammatory diseases. The Athos drug development platform begins with over 25,000 high-quality patient samples sourced from premier global hospital systems. Athos' AI2 platform identifies novel drug targets by integrating multi-omic and longitudinal clinical datasets and matches them to its small molecule computational chemistry platform. The AI2 platform includes the Athos data lake, singular well-established omics workflows, and an integrative deep machine learning engine. The company's lead drug compound is ATH-063, an investigational, oral small molecule G9A inhibitor for inflammatory bowel disease.Athos is also developing a pipeline of additional small molecule approaches for various autoimmune diseases.Additional information about Athos Therapeutics can be found at https://athostx.com/Contact:Athos Therapeutics, Inc.Keith Hoffman, PhD, Chief Business Officerkhoffman@athostx.comSOURCE: Athos Therapeutics, Inc. Copyright 2024 ACN Newswire via SeaPRwire.com.