วัน: 24 เมษายน 2025

HONG KONG, Apr 24, 2025 - (ACN Newswire via SeaPRwire.com) – HighTide Therapeutics, Inc. (2511.HK), a clinical stage biopharmaceutical company specializing in the development of multifunctional multi-targeted therapies for chronic liver and metabolic diseases, announced today that it will present at the EASL Congress 2025, taking place from May 7-10, 2025 in Amsterdam. The presentations include post-hoc analyses of two Phase 2 clinical studies of berberine ursodeoxycholate (HTD1801), a gut-liver anti-inflammatory metabolic modulator, being developed for treatment of metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2DM). A third presentation will present preclinical results for rimtoregtide (HTD4010), a peptide derived from the Reg3a protein, in liver failure in mice.“Effects of Berberine Ursodeoxycholate (HTD1801) in Patients with At-risk MASH and T2DM”(Presentation SAT-440, Poster Presentation, May 10, 8:30 AM CET)About the Abstract: Due to the ongoing unmet medical need, clinical development in MASH focuses on patients who are at a higher risk of disease progression and outcomes due to the presence of moderate to advanced fibrosis (defined as at-risk MASH). The purpose of this analysis was to assess the effects of HTD1801 in patients with at-risk MASH and T2DM as defined by baseline MRI cT1 >875 ms. Eighteen weeks of treatment with HTD1801 resulted in substantial improvements in key hepatic and cardiometabolic parameters in patients with at-risk MASH and compared to placebo, twice as many patients achieved a reduction in liver fat content (MRI-PDFF) or fibroinflammation (cT1) that have been associated with improvements in liver histology. These data are particularly insightful as HTD1801 continues to be evaluated in an ongoing paired biopsy study of patients with at-risk MASH and pre-diabetes or diabetes.“Effects of Berberine Ursodeoxycholate (HTD1801) in Chinese Patients with T2DM and Presumed MASLD”(Presentation SAT-432, Poster Presentation, May 10, 8:30 AM CET)About the Abstract: T2DM typically coexists with other metabolic abnormalities such as hyperlipidemia, obesity, and MASH that can exacerbate T2DM and can lead to a worse prognosis with increased risk for mortality and cardiovascular outcomes. In a Phase 2 study in patients with T2DM, HTD1801 achieved the primary endpoint with a significant decrease in HbA1c. Based on the latest diagnostic criteria, it is likely that a substantial subgroup of the study may have had concurrent metabolic dysfunction-associated steatotic liver disease (MASLD). The purpose of this analysis was to evaluate the benefits of HTD1801 in patients with T2DM and MASLD identified by baseline controlled attenuation parameter values >288 dB/M (correlated to 5% liver fat content). HTD1801 treatment demonstrated both dose-dependent improvements in cardiometabolic and hepatic parameters in patients with T2DM and MASLD. These data suggest HTD1801 can comprehensively address metabolic and cardiovascular risk factors beyond glycemic control.“A Comparison of the Protective Effects of Rimtoregtide (HTD4010) and DUR-928 on Acute Liver Failure in Mice”(Presentation FRI-141, Poster Presentation, May 9, 8:30 AM CET)About the Abstract: The purpose of this study was 1) to test the potential protective effects of HTD4010 in an LPS-induced model mimicking acute liver failure in mice and 2) compare these effects to DUR-928, which is currently in late-stage development for the treatment of alcohol-associated hepatitis. In an LPS-induced mouse model mimicking acute liver failure, HTD4010 resulted in significant improvement in survival rates (greater than 2-fold) compared to the model control.  These protective effects of HTD4010 were significantly greater than DUR-928.  These findings provide evidence that HTD4010 may have a beneficial effect on acute liver conditions including alcohol-associated hepatitis and other acute-inflammatory-related conditions.About Berberine UrsodeoxycholateBerberine ursodeoxycholate (HTD1801) is an orally delivered, gut-liver anti-inflammatory metabolic modulator being developed for the treatment of metabolic and digestive diseases. HTD1801, an ionic salt of berberine and ursodeoxycholate, is a new molecular entity with a unique dual mechanism of action: AMP kinase activation and NLRP3 inflammasome inhibition. These two key mechanistic pathways have been associated with improvements in insulin resistance, glucose metabolism, lipid metabolism, and hepatic inflammation, potentially providing a comprehensive treatment platform for the multifaceted nature of complex metabolic diseases. HTD1801 is being developed for multiple indications. HTD1801 met the primary endpoint in two Phase 3 clinical trials in patients with type 2 diabetes mellitus (T2DM), demonstrating a clinically meaningful effect on HbA1c. In both trials, key secondary endpoints were achieved, suggesting multiple advantages of HTD1801 including improvement in cardiometabolic risk indicators. In addition to T2DM, HTD1801 efficacy in treating metabolic dysfunction-associated steatohepatitis (MASH) has been demonstrated in a Phase 2a clinical trial, and a global multicenter Phase 2b trial assessing the histologic benefit of HTD1801 is currently ongoing, with topline results expected in 2025.About RimtoregtideRimtoregtide (HTD4010) is a clinical-stage compound in development for acute inflammatory-related indications including alcoholic hepatitis (AH). It is a peptide derived from the Reg3a protein with immunomodulatory, anti-inflammatory, and anti-apoptotic effects. HTD4010 has been evaluated in animal models of acute pancreatitis and acute liver failure, where protective effects were observed. A completed Phase 1 clinical trial of HTD4010 in healthy subjects demonstrated a favorable safety profile. AH is caused by chronic heavy alcohol abuse or a sudden, drastic increase in alcohol consumption. It is characterized by severe inflammation and, ultimately, liver failure and death. There is currently no approved treatment for AH and only a few drug candidates are in clinical development. The current standard of care focuses on symptom management, including abstinence, treating inflammation and providing nutrition.About HighTide TherapeuticsHighTide Therapeutics, Inc. (Stock Code: 2511.HK) is a globally integrated biopharmaceutical company focusing on the discovery and development of first-in-class multifunctional, multi-targeted therapies with poly-indication potential across metabolic diseases with significant unmet medical needs. HighTide is currently developing several clinical assets and associated global intellectual property rights, and advancing multiple mid-to-late-stage clinical trials including therapies for metabolic dysfunction-associated steatohepatitis (MASH), type 2 diabetes mellitus (T2DM), severe hypertriglyceridemia (SHTG) and primary sclerosing cholangitis (PSC). Berberine ursodeoxycholate (HTD1801), HighTide’s lead drug candidate, received Fast Track designation from the United States Food and Drug Administration for both MASH and PSC and Orphan Drug designation for PSC. HTD1801 has been included in the National Major New Drug Innovation Program under the 13th Five-Year Plan for Major Technology Project in China.For more information, please visit www.hightidetx.comContact: pr@hightidetx.com Copyright 2025 ACN Newswire via SeaPRwire.com.

JAKARTA, Apr 24, 2025 - (ACN Newswire via SeaPRwire.com) - South East Asia’s first premium service airline, PT TransNusa Aviation Mandiri, is further strengthening its presence in Singapore by increasing the frequency of its scheduled flights for the Jakarta – Singapore route to two times daily from today.This announcement comes barely a month after TransNusa successfully launch scheduled flights to Perth from its base in Bali.TransNusa Group Chief Executive Officer, Datuk Bernard Francis said that TransNusa has plans to further strengthen its network connectivity this year.In line with this, TransNusa launched its second daily flight to Singapore today. The additional flight, 8B 153, departed at 12.10pm from the Terminal 3 Soekarno – Hatta International Airport and arrived Singapore Changi Airport at 14.40pm today. While its additional flight, 8B 154, departed Changi Airport at 15.30pm and arrived at the Soekarno – Hatta International Airport at 16.20pm.“TransNusa will continue to operate the current scheduled flight, 8B 151, which depart Soekarno – Hatta International Airport at 07.55am and arrive at 10.45am at the Changi Airport,” Datuk Bernard said, adding that the current flight, 8B 152, depart Changi Airport at 11.45am and arrive in Jakarta at 12.30pm.TransNusa has been consistently achieving milestones since the introduction of a new top management led by aviation veteran, Datuk Bernard Francis. The airline, which introduced its first international flight on April 14, 2023, has expanding its wings from South East Asia to the Asia Pacific region within a short span of 2 years.Datuk Bernard attributes the airline’s successes and accelerated growth within the last 24 months to their customised business model and the vastly experienced management team.Datuk Bernard stressed that for its international flights, TransNusa not only provide premium services with competitive ticket prices, but the airline also has attractive product bundles called SEAT, SEAT-PLUS and FLEXI-PRO."Our passengers will enjoy check-in baggage of between 20kgs to 30 kgs, depending on the product purchased,” Datuk Bernard said, explaining that the baggage offering was over and above the 7kgs limit offered as a passenger’s hand carry.“For the highest package, FLEXI-PRO, we provide more complete services such as free baggage 30kgs, free to choose seats, free food, and drinks, priority at check-in and boarding. In addition, TransNusa also provides its FLEXI-PRO passengers with the ability to be able to change their flight schedule without restrictions and obtain refund when needed.”TransNusa, which aims to ensure its passengers travel with ease and comfort, has also configured their A320s with a 174-seat configuration, which allows for passengers to enjoy about 30 inches of legroom, comparable to the experience passengers would get in a full-service airline."We are committed to providing affordable and competitive ticket prices, while still providing premium services to our customers.” said Datuk Bernard, adding that the ticket price for the Jakarta – Singapore route starts from as low as SGD52 (USD40).DATUK BERNARD FRANCIS… TransNusa to focus on strengthening network connectivityTransNusa, A Short HistoryTransNusa, which had to close it business operation in September 2020 due to impact of the Covid-19 pandemic on the aviation industry, started operations again after injection of new shareholders and a new management team led by aviation expert, Datuk Bernard, in October 2022.Within 6 months, the airline introduced its first international route between Jakarta and Kuala Lumpur and celebrated its first-year anniversary for this route on April 14, 2024.“When we re-launched TransNusa in October 2022, we started from the bottom again. Everything was new because the pandemic had disrupted the aviation business operations boundaries. As such we re-created and customised our business operations and strategy model of being the first Premium Service Carrier based on the post-pandemic scenario,” Datuk Bernard explained.TransNusa launched its first international route between Jakarta and Kuala Lumpur in April, 2023, followed by the Jakarta – Singapore route on November 20, 2023. After which, the airline successfully launched three more new international routes by the end of 2023. TransNusa’s aggressive international growth strategy combined with its domestic business operations approach has enabled the airline to experience strategic growth in the last two years.Since the takeover of new shareholders and the injection of a new management team, TransNusa has been making headlines in Malaysia, Singapore, China and Australia with news of being the first airline in Indonesia and the world to develop and introduce a new domestic route connecting Bali and Manado. TransNusa also became the second Indonesian airline to receive approval to fly to China.About TransNusaEstablished in 2005, TransNusa started its operation by providing chartered flights. It began its commercial flights in 2011. After ceasing operations due to the Covid-19 pandemic, TransNusa relaunched itself in 2021 as a low-cost airline in its domestic market. In 2023, TransNusa introduced a new business model making it the first Premium Service Airline in the region. The new business model will apply only to its international routes. TransNusa introduced its first international route in April this year. The airline introduced its Jakarta – Kuala Lumpur round trip route and had its maiden flight on April 14. The airline is currently based in Jakarta Soekarno-Hatta International Airport.Passengers can book their flights on the TransNusa website (www.transnusa.co.id), through authorized travel agents in Singapore and Indonesia, or by contacting the airline's customer service centre at, +62216310888. For the Singaporean market, passengers can contact TransNusa’s General Sales Agent, Chariot Travels Pte Ltd, at +65 86602719.Media ContactTrina Thomas Rajtrina@myqaseh.org+60124992672 (watsapp) Copyright 2025 ACN Newswire via SeaPRwire.com.

WATERLOO, ONTARIO, Apr 23, 2025 - (ACN Newswire via SeaPRwire.com) - Axibo Inc., a Waterloo-based robotics innovator celebrated for its groundbreaking 4D volumetric capture technologies and serving customers like Netflix and Apple, today announced a $12 million funding round. This investment includes $11 million from prominent external investors and an additional $1 million from Axibo's founders Anoop Gadhrri, Sohaib Al-Emara, and Reiner Schmidt, whose passion for robotics began back in 2019 with their university's first autonomous vehicle. The funding launches Axibo's ambitious new division dedicated to advanced humanoid robotics.Axibo FoundersWith a track record of thousands of cinema robots delivered internationally, Axibo will now be leveraging Waterloo's exceptional AI, robotics, and precision engineering talent to spearhead advancements in humanoid robotics."We see humanoid robots as the next major milestone in productivity since the Industrial Revolution," said Anoop Gadhrri, co-founder and CEO of Axibo. "Canada is exceptionally well-positioned with its talent and resources. Our commitment is to drive this forward, placing Canada prominently on the global robotics stage."Axibo is actively seeking visionary engineers passionate about developing unprecedented technologies and shaping the global future of humanoid robotics. Early team members will not only create groundbreaking prototypes but directly contribute to substantial societal advancements through robots engineered for safe and intelligent integration into healthcare, logistics, industrial automation, and personal assistance. By fostering an innovation-driven culture emphasizing rapid prototyping and autonomy, Axibo empowers its engineers to experiment freely and iterate swiftly."We envision a future where every household benefits from humanoid robotics," Gadhrri emphasized. "Axibo's technology aims to significantly elevate productivity and everyday life across Canada and beyond."The company's immediate milestones include accelerating proprietary manufacturing processes, expanding its engineering and AI teams, and advancing capabilities in robot autonomy and dexterity. The new division's first robot prototype, temporarily code-named "T.E.B.", will debut in early 2026, demonstrating advanced agility and intelligence.If you're ready to build what's next in robotics, Axibo invites you to join the pioneering team positioning Canada at the global forefront of robotics innovation.To learn more or apply, visit axibo.ai.Contact InformationAnoop GadhrriCEOanoop@axibo.com6476675999SOURCE: Axibo Inc.Related Images Copyright 2025 ACN Newswire via SeaPRwire.com.

KUALA LUMPUR, Apr 23, 2025 - (ACN Newswire via SeaPRwire.com) - EdgePoint Towers Sdn Bhd (“EdgePoint”) – part of EdgePoint Infrastructure, a leading ASEAN-based independent telecommunications infrastructure company, has successfully launched its first solar hybrid site, marking a key milestone in its renewable energy initiatives. This deployment represents a significant step toward advancing sustainable energy solutions in Malaysia’s telecommunications sector.The new solution provides up to 100% of the energy required to operate telecommunications equipment, reducing dependence on diesel fuel. With a 5.9-kilowatt peak (kWp) capacity, the site operates autonomously using photovoltaic (solar) energy, complemented by battery storage.Muniff Kamaruddin, Chief Executive Officer of EdgePoint Towers, said, “We are proud to contribute to the deployment of renewable energy solutions that meet current and future needs for both sustainability and long-term cost efficiency. These solutions are especially important for remote and difficult-to-reach areas, such as transport corridors like highways, tunnels, bridges, or terminals, where quality coverage is essential for transient users. The opportunities to enhance national connectivity are vast, and EdgePoint is eager to continue working closely with our partners to advance sustainable solutions that improve coverage and reduce carbon emissions across the industry. This deployment is expected to reduce the site's annual carbon emissions by approximately 78%, while also ensuring seamless connectivity for travelers along the highway.”Muniff concluded, “Solar energy has proven to be an ideal solution for Malaysia, given its equatorial climate and high levels of solar insolation. By integrating solar power into telecommunications infrastructure, we are reducing reliance on non-renewable energy sources, lowering operational costs, and significantly decreasing emissions. Solar hybrid solutions are an adjacent focus area for us, it is a key part of our broader strategy of implementing innovative, sustainable solutions, driving an industry-wide transformation toward cleaner, more efficient operations and we are optimistic about future collaborations with both Mobile Network Operators (MNOs) and non-MNO clients to help them meet their green objectives. As we expand our renewable energy initiatives, we aim to set new benchmarks for energy-efficient telecom infrastructure in Malaysia, helping our partners transition to greener operations without compromising connectivity, network quality, and reliability.”By the end of 2025, EdgePoint plans to complete more full solar or solar hybrid sites across the country, further strengthening its commitment to sustainable telecom infrastructure.EdgePoint Infrastructure is the fastest-growing multi-country tower company in ASEAN, with 15,800 sites in its portfolio out of which 1,800 sites are in Malaysia making it the second-largest tower company in Malaysia.****ABOUT EDGEPOINT INFRASTRUCTUREEdgePoint Infrastructure is an ASEAN based independent telecommunications infrastructure company that aspires towards Building a Connected, Digital ASEAN. Headquartered in Singapore with operations in Malaysia, Indonesia and the Philippines, through EdgePoint Towers Sdn Bhd, PT Centratama Telekomunikasi Indonesia, Tbk and EdgePoints Towers Inc. respectively, the company is focused on providing sharable and leading-edge telecom structures, small cells and in-building systems. EdgePoint aims to be an industry leader through scale and innovation, driving operational efficiencies through the adoption of analytics and digital technologies. For more information on EdgePoint, please visit https://edgepointinfra.com/.  Copyright 2025 ACN Newswire via SeaPRwire.com.

HONG KONG, Apr 23, 2025 - (ACN Newswire via SeaPRwire.com) – On 22 April, Earth Day, an electrifying cycling event was held across Guangdong and Macau. Batch Bicycles and Hyatt Place Zhuhai jointly organised Ride Macao, an event to explore the country on wheels and celebrate Earth's Day with green travel.In today’s fast-paced city life, people are often busy with work and various affairs that they gradually leave nature and sports behind. The Ride Macao event was designed to break this shackle and spread the values of living green, protecting the environment and the cycling lifestyle to everyone.Starting from Hyatt Place Zhuhai and arriving at Hengqin Port, the carefully planned route combined the picturesque natural scenery and unique cityscape along the way with the ease of cruising through customs. Riders enjoyed the magnificent view of the sea and sky during the journey while also experiencing the unique charm of the blend of history and modernity found along the streets and lanes of Macau. This was not only a long-distance ride, but also a deep dialogue with the earth to embrace green living.Ride Macau by Batch Bicycles (a brand of Covation)Batch Bicycles Products DisplayBatch Bicycles is a global brand of Covation Holdings Limited (Covation). Covation is a global holding company headquartered in Hong Kong. Covation's vision of consumer-centric innovation is driven by its diverse portfolio of outdoor brands, including Huffy, Niner Bikes, Batch Bicycles, Royce Union, VAAST and Buzz E-Bikes, which are available to consumers in more than 50 countries and territories around the world through an extensive global distribution network.  The company ships more than 5 million bicycles annually. Covation holds a wide-ranging licensing portfolio with world-class partners such as Disney, Marvel, Lucasfilm, National Geographic, Ford, Nickelodeon, Hasbro, and Panama Jack. The vast distribution network includes leading global retailers such as Walmart, Amazon, Target, Swire, Big W, Academy, Argos, Smyths, and many other international outlets.The mission of Batch Bicycles is to 'make cycling easier'. With a wide range of products including mountain bikes for conquering mountains, road bikes for riding the pavement, gravel bikes and cycling equipment specially designed for teenagers. Batch Bicycles are designed to provide cycling enthusiasts around the world with a comfortable and smooth cycling experience through innovative designs and high-quality configurations. The Macao Ride is a vivid manifestation of Batch Bicycles brand philosophy to make cycling easier and encourage people to venture out of the concrete city to explore the world and embrace nature through cycling. Copyright 2025 ACN Newswire via SeaPRwire.com.