วัน: 2 กันยายน 2025

Massachusetts, USA, September 2, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Corporation ("MC”) is pleased to announce its participation in a third-party allotment of shares by Commonwealth Fusion Systems LLC (Headquarter: Massachusetts, USA, Representative: Bob Mumgaard, “CFS”), a fusion energy start-up originating from MIT *1. This investment was made in collaboration with a consortium of 12 Japanese companies *2 (“Japanese Consortium”). In the field of fusion energy, this investment builds on MC’s previous investment in Kyoto Fusioneering Ltd., announced on May 17, 2023.*1 Massachusetts Institute of Technology*2 MC, Mitsui & Co., Ltd., Kansai Electric Power Co., Inc., JERA, Mitsui O.S.K. Lines, Ltd., JGC, Development Bank of Japan, Inc., NTT Corporation, Fujikura Corporation, Sumitomo Mitsui Banking Corporation, Sumitomo Mitsui Trust Bank, Limited, Mitsui Fudosan Co., Ltd.Fusion energy is produced when two light nuclei, typically deuterium and tritium, collide to form a single heavier nucleus, helium. This is the same process that powers the Sun and other stars. Since no carbon dioxide is emitted during power generation and the fuel is abundantly available in seawater, fusion offers an almost inexhaustible energy source. A small amount of fuel can produce a tremendous amount of energy. Fusion is gaining global attention as a next-generation energy source that supports decarbonization and ensures a stable energy supply. In June 2025, the Japanese government revised its “Fusion Energy Innovation Strategy,” which outlines the development and promotion of fusion energy. This policy aims to position Japan as a global leader in power generation by the 2030s.CFS, a spin-off company of MIT, is the world’s leading and largest private fusion company, utilizing the magnetic confinement system (tokamak type) *3. The company plans to build the world's first commercial fusion power plant "ARC" in Virginia in the United States, with the intent of generating electricity in the early 2030s. In June of this year, CFS announced that it signed a power purchase agreement with Google for 200 megawatts of electricity from its first ARC power plant.The Japanese Consortium will acquire technical and commercial expertise in policy, regulatory, and the development, construction, operation, and maintenance of ARC from CFS's commercialization projects in the United States. In addition, each consortium company will bring together its know-how and expertise and aspire to expedite the commercialization and industrialization of fusion energy power generation in Japan.The collaboration between the Japanese Consortium and CFS is consistent with the Japan – U.S. joint partnership to accelerate the development and commercialization of fusion energy power generation in Japan and the United States, and represents a strong commitment and growing momentum toward the early realization of commercialization in both countries.*3 A torus-shaped fusion energy device that uses a strong magnetic field to confine ultra-high temperature plasmaThrough this investment, MC seeks to acquire cutting-edge knowledge in fusion energy and contribute to both decarbonization and a stable energy supply by leveraging its extensive networks and industrial capabilities to support the practical application of fusion technologies.MaterialityBased on the Three Corporate Principles, which serve as MC’s core philosophy, MC has continued to grow together with society by contributing to the sustainable development of society through its business activities while pursuing value creation. While continuously creating Shared Value guided by the Materiality, a set of crucial societal issues, MC will continue to strengthen its efforts towards sustainable corporate growth. Guided by this Materiality, MC will continue to strengthen its efforts towards sustainable corporate growth. Out of the six material issues relating to “Realizing a Carbon Neutral Society and Striving to Enrich Society Both Materially and Spiritually”, this project’s activities particularly support "Contributing to Decarbonized Societies", “Promoting Stable, Sustainable Societies and Lifestyles” and “Utilizing Innovation to Address Societal Needs”.Inquiry RecipientMitsubishi CorporationTelephone:+81-3-3210-2171 Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO, September 2, 2025 - (JCN Newswire via SeaPRwire.com) - Hitachi, Ltd. (TSE:6501, "Hitachi") has been certified as a Gold Partner*1 of Scaled Agile, Inc. ("SAI"), the provider of SAFe®, the world's most trusted system for business agility.SAFe is a management framework that supports organizational transformation and business agility, helping to enhance competitiveness and maximize customer value and is widely adopted globally. Within the Hitachi Group, GlobalLogic was certified as a Silver Partner of SAI in 2021 and has been supporting agile DX transformation based on customer experience.Amid increasingly rapid social change and growing uncertainty, Hitachi will apply SAFe as a common framework across One Hitachi to support customers globally in rapidly adapting to change and continuously creating value. For example, by applying SAFe to the implementation of "HMAX*2", which embodies Lumada 3.0 and aims to solve customer and societal challenges by converting data into value using Hitachi's domain knowledge and AI, Hitachi seeks to accelerate the value delivery cycle.Going forward, through this certification and as part of SAI's official partner network, Hitachi will utilize SAFe as a methodology for enterprise-level agile development. Hitachi will flexibly and continuously support system development management that is aligned with customers' business strategies in response to changes in society and the market environment. Additionally, Hitachi will establish a framework for implementing SAFe within the company and systematically advance human resource development to increase the number of employees with SAFe expertise to 5,000, thereby strengthening practical capabilities and agility.Through these efforts, Hitachi will accelerate social innovation and contribute to the realization of a "Harmonized Society" where environment, wellbeing, and economic growth coexist in harmony.*1 Certification awarded to organizations with five or more certified SAFe consultants (SPCs) who are recognized as capable of leading agile transformations for customers at the enterprise level.*2 September 24, 2024: Hitachi Rail Unveils the ‘HMAX’ AI Solution, Accelerated by NVIDIA, to Optimize Trains, Signaling and Infrastructurehttps://www.hitachi.com/New/cnews/month/2024/09/240924c.htmlBackgroundIn recent years, agile methodologies have become increasingly widespread in system development as companies seek to respond flexibly to uncertain and rapidly changing market environments and strengthen their competitiveness. Hitachi launched its "Agile Development Consulting Service" in 2019 with the aim of providing efficient system development and high-quality IT services. In addition, Hitachi has responded to numerous agile development projects to quickly address changes in our customers' business strategies and market needs, contributing to the enhancement of their experience value. Furthermore, Hitachi has actively worked to improve the speed, flexibility, and scalability of system development by adapting the agile development methodologies used at GlobalLogic for the Japanese market, and applying them to enterprise systems that support the core of business operations. Today, rapid development and service delivery aligned with changes in society and market conditions require organizations to undergo transformation in sync with their corporate strategies.As a result, there is a growing need to leverage proven management frameworks that enhance business agility by flexibly translating those requirements into system development.Future Initiatives1. Strengthening System Development Management Aligned with Customer Business Strategies.Hitachi will leverage SAFe through this partner certification to further accelerate Social Innovation Business by leveraging its strengths in IT, OT, and products. Specifically, we will adopt SAFe, a management framework aligned with business strategy, as a standard methodology for enterprise-level agile system development to enhance business agility. This will enable us to respond flexibly and swiftly to future changes in the business environment, thereby contributing to our customers' sustainable growth and accelerated digital transformation.2. Advancing Human Resource Development.In addition to its framework, SAFe provides certified training courses and agile development coaching for members. Hitachi will utilize these resources to further focus on developing agile human resources, increasing the number of employees with SAFe knowledge to 5,000. Additionally, through Gold Partner certification, Hitachi will gain direct access to the latest insights and training programs from SAI, as well as global best practices from the SAFe partner network worldwide, and will actively utilize these resources.Through these initiatives, Hitachi will systematically establish a framework for SAFe implementation and human resource development within the company, thereby strengthening its practical capabilities and agility from a human resource perspective.Hitachi will continue to promote Social Innovation Business that leverage agile development methods and digital technologies to solve the challenges faced by our customers and society. We will also maximize the knowledge and global network we have cultivated as a SAFe partner to accelerate our customers' DX and contribute to the enhancement of their corporate value.Comments from Phil Knight - VP, Partner Alliances, Scaled Agile, Inc."We are delighted to welcome Hitachi, Ltd. as a Gold Partner in the Scaled Agile Partner Network. By leveraging SAFe® to drive enterprise-wide agile transformation and applying it to their platforms and solutions, Hitachi will further maximize customer value creation. Through this partnership, we look forward to accelerating the adoption of business agility across Japan more than ever before."About Hitachi, Ltd.Through its Social Innovation Business (SIB) that brings together IT, OT(Operational Technology) and products, Hitachi contributes to a harmonized society where the environment, wellbeing, and economic growth are in balance. Hitachi operates globally in four sectors – Digital Systems & Services, Energy, Mobility, and Connective Industries –and the Strategic SIB Business Unit for new growth businesses. With Lumada at its core, Hitachi generates value from integrating data, technology and domain knowledge to solve customer and social challenges. Revenues for FY2024(ended March 31, 2025) totaled 9,783.3 billion yen, with 618 consolidated subsidiaries and approximately 280,000 employees worldwide. Visit us at www.hitachi.com.Business ContactProject Management DivisionDigital Systems & Services Business ManagementDivisionDigital Systems & Services Business DivisionHitachi, Ltdspc-info@ml.itg.hitachi.co.jp  Copyright 2025 JCN Newswire via SeaPRwire.com.

KARIYA, JAPAN, September 1, 2025 - (JCN Newswire via SeaPRwire.com) - DENSO CORPORATION (hereinafter “DENSO”) today announced that its Board of Directors has resolved to transfer its Spark Plug and Exhaust Gas Sensor business (Oxygen Sensor and Air-Fuel Ratio Sensor), to Niterra Co., Ltd (hereinafter “Niterra”). The two parties reached a decision to sign the business transfer agreement during a board of directors meeting on September 1st, 2025.In the process of achieving a carbon neutral society, electrified vehicles are expected to become more widespread throughout the auto industry. At the same time, powertrain diversification is expected to continue progressing, in response to differing energy and fuel needs across regions and countries. In such market environment changes, DENSO recognizes that advancing product innovation across all domains and establishing a sustainable supply framework aligned with the anticipated market scale, are challenges for the entire auto industry.Under all these factors, on July 10, 2023, DENSO completed an MOU* to transfer business operations for select internal combustion engine parts to Niterra, which boasts some of the world’s leading technologies in its field.Since then, through extensive discussions and deliberations, the two parties reached an agreement on the business transfer. This decision was made while sharing a common understanding of a strong commitment to the technology and quality of Spark Plug and Exhaust Gas Sensor. Through this transfer, both companies will enhance the product capabilities of internal combustion engines, by integrating technologies and manufacturing capabilities shared by each other.DENSO will continue to maximize its resources in the fields of electrification and clean energy, such as hydrogen, which are expected to see increased adoption, aiming for sustainable growth of these businesses.Going forward, DENSO will continue to steadily advance these initiatives through thoughtful and ongoing dialogue with stakeholders, including customers, business partners and employees. By leveraging the broad technological platform cultivated over many years, DENSO will play a key role in providing diverse solutions across the auto industry, responding to market needs around the world, and contributing to the realization of a sustainable, carbon-neutral society.The transfer will take place only after official approval has been obtained from competition law authorities in all countries and regions concerned, and after fulfilling all other requirements.Overview of the Business Transfer1. Target Business: Spark Plug and Exhaust Gas Sensor business (Oxygen Sensor and Air-Fuel Ratio Sensor)2. Signing Date of the Agreement: September 1, 20253. Transfer Execution Date: To be determined, pending completion of approvals from competition law authorities in all countries and regions concerned, and after fulfilling all other requirements  Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO, Japan, September 1, 2025 - (JCN Newswire via SeaPRwire.com) – Honda Motor Co., Ltd. (Honda), an official global partner of the World Athletics Championships Tokyo 25 (WCH Tokyo 25), today revealed the list of Honda vehicles to be used as the official vehicles for WCH Tokyo 25, to be held September 13 through 21, 2025.With its theme for WCH Tokyo 25 — “Maximizing the excitement and inspiration from the athletes’ great performance, through the realization of an environmentally-responsible and safe event by providing a wide variety of mobility products equipped with innovative technologies”— Honda will provide a diverse lineup of approximately 120 vehicles, mostly environmentally-responsible vehicles, including fuel cell electric vehicles (FCEVs), battery electric vehicles (BEV) and hybrid electric vehicles (HEVs). All Honda vehicles to be provided as official vehicles will feature a special wrap designed exclusively for the WHC Tokyo 25. Intended useModelCompetition operationMen’s and Women’s MarathonChief Judge’s vehicleCR-V e:FCEVOfficial timing vehicleN-VAN e:Course check vehicleAll-new PreludeCourse check vehicleN-ONE e:Camera bikesCUV e:Supplying electricity to antenna mats for measurement split timesPower Exporter e: 6000 / 9000Throwing eventsRadio-controlled car for retrieval and transportation of throwing implements1/4 model of Honda 0 SUV PrototypeOverall event operationTransportation vehiclesCR-V e:FCEVStep WGN e:HEV modelOdyssey e:HEV modelZR-V e:HEV modelPersonal mobility devicesUNI-ONEStriemo (product of Striemo, Inc.*1)*1 A company originated from the Honda new business creation program, IGNITION.To support men’s and women’s marathon races, the CR-V e:FCEV fuel cell vehicle will serve as the Chief Judge’s vehicle, and N-VAN e: commercial-use mini-EV equipped with Seiko timing equipment will serve as the official timing vehicle. In addition, Honda will provide the Power Exporter e: 6000 and Power Exporter e: 9000 portable external power output devices, which will take electricity from the N-VAN e: and supply electricity to mat antennas stationed at each 5km point on the course to measure the 5km splits of each runner. Men’s/Women’s Marathon Chief Judge’s vehicle(Honda CR-V e:FCEV)Men’s/Women’s Marathon official timing vehicle(Honda N-VAN e:)The all-new Prelude specialty sport model and all-new N-ONE e: mini-EV will be used as course check vehicle to ensure a safe environment before each race. Both vehicles are all-new models scheduled to go on sale in fall 2025. Moreover, the CUV e: electric personal commuter model capable of two-up riding powered by the Honda Mobile Power Pack e: swappable battery will be used as camera bikes to capture the performances of the runners.For the transportation of WCH Tokyo 25 personnel and participants, Honda will provide the CR-V e:FCEV fuel cell electric vehicle, as well as hybrid-electric models, including Step WGN e:HEV, Odyssey e:HEV and ZR-V e:HEV.Furthermore, to enhance mobility and help reduce the workload of WCH Tokyo 25 staff and other stakeholders supporting operation of the WCH Tokyo 25, will utilize Honda UNI-ONE, a hands-free seated personal mobility device the user can steer simply by shifting body weight while sitting.Vehicle exhibit inside the stadium and radio-controlled car for event operations supportDuring the WCH Tokyo 25, for the first time in the history of the World Athletics Championships, a vehicle exhibit will be placed inside the stadium. The vehicle to be on display at the Japan National Stadium is the Honda 0 SUV Prototype. The production model based on this prototype model is scheduled to go on sale first in North America in 2026, followed by global sales. In addition, Honda produced a 1/4 scale radio-controlled model of the Honda 0 SUV Prototype exclusively for the WCH Tokyo 25. This RC car will be used in the throwing events — javelin, hammer, and discus — to retrieve throwing implements and transport them quickly and safely, thereby reducing the workload of staff and contributing to the smooth operation of the throwing events. Image of in-stadium exhibit of Honda 0 SUV Prototype1/4 scale radio-controlled model of Honda 0 SUV PrototypeHonda mobility products exhibit outside the stadium Honda mobility products which will support the WCH Tokyo 25 will be exhibited in an area in front of the Tokyo Metropolitan Gymnasium, adjacent to the National Stadium. The exhibit will feature immersive backgrounds and other effects to create the impression as if the vehicles are in motion, which will offer a unique photo spot for visitors. Moreover, visitors will be able to take photos on the CUV e:, the police motorcycle version of Honda NT1100, and the UNI-ONE. These exhibits are designed to offer experiences through which visitors can feel more connected to the WCH Tokyo 25.PreludeUNI-ONE (with special WCH Tokyo 25 wrap)Honda vehicles and devices on displayAutomobiles:All-new Prelude,N-VAN e: (with special WCH Tokyo 25 wrap)Motorcycles:CUV e: (with special WCH Tokyo 25 wrap)NT1100 (police motorcycle version)Next-generation mobility:UNI-ONE (with special WCH Tokyo 25 wrap)Radio-controlled car:1/4 scale radio-controlled model of Honda 0 SUV Prototype to be used for retrieval of throwing implements: About WCH Tokyo 25Event Name: World Athletics Championships Tokyo 25Organizer/Host: Organizer: World AthleticsHost: Japan Association of Athletics Federations (JAAF)Event Period: September 13 – 21, 2025 (9 days)Number of Participating Countries and Territories: Approximately 200Number of Participating Athletes: Approximately over 2,000Event Venue: Japan National Stadium and other facilities in Tokyo, JapanHonda special World Athletics website Honda will continuously share its stories and passion for supporting athletes who take on challenges in the WCH Tokyo 25 and introduce a wide variety of Honda vehicles serving active roles during the event.URL:https://global.honda/jp/WorldAthletics/ (Japanese)https://global.honda/en/WorldAthletics/ (English)Based on the Honda vision for its sports activities – “To increase the number of people who take on challenges through sports activities and make the lives of all people more enjoyable” – Honda will continue to support various athletes who take on challenges toward the realization of their own dreams. Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO and CAMBRIDGE, MA, August 30, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) and Biogen Inc. (Nasdaq: BIIB, Headquarters: Cambridge, Massachusetts, CEO: Christopher A. Viehbacher, “Biogen”) announced today that the U.S. Food and Drug Administration (FDA) has approved the Biologics License Application (BLA) for once weekly lecanemab-irmb subcutaneous injection (U.S. brand name: LEQEMBI® IQLIKTM, pronounced “I Click”) for maintenance dosing. LEQEMBI IQLIK is a subcutaneous autoinjector (SC-AI) developed by Eisai, containing 360 mg/1.8 mL (200 mg/mL) that can be administered in approximately 15 seconds. LEQEMBI IQLIK autoinjector is indicated for maintenance dosing to treat Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) or mild dementia stage of disease(collectively referred to as early AD) in the U.S. After 18 months of LEQEMBI (lecanemab-irmb) intravenous(IV) treatment at 10 mg/kg every two weeks, patients may either continue IV infusions at 10 mg/kg once every four weeks or start the new weekly 360 mg subcutaneous injection using the LEQEMBI IQLIK autoinjector.Clinical Trials Supporting Subcutaneous Maintenance Dosing ApprovalThe BLA is based on LEQEMBI subcutaneous (SC) sub-studies of the Phase 3 Clarity AD open-label extension (OLE) trial in individuals with early AD, which evaluated a range of subcutaneous doses. Data shows that transitioning to the weekly LEQEMBI IQLIK autoinjector after 18 months of the initiation dose (10 mg/kg IV every two weeks) maintains clinical and biomarker benefits comparable to continued IV dosing.The safety of LEQEMBI IQLIK autoinjector was studied in over 600 patients at a range of doses as part of the Clarity AD OLE.49 patients received a weekly 360 mg subcutaneous maintenance dose after at least 18 months of 10mg/kg IV every two weeks. Importantly, none of these patients experienced any local or systemic injection-related adverse events (AEs).Across all subcutaneous doses, the safety profile was similar to that of the IV maintenance treatment with one key difference: systemic reactions were much less common with subcutaneous dosing—less than 1% compared to approximately 26% with IV infusions. Approximately 11% of patients experienced mild-to-moderate local reactions (such as redness, swelling or itching at the injection site), which did not interfere with continued administration, and less than 1% had mild systemic symptoms such as headache, fever or fatigue.ARIA rates in patients who received a weekly 360 mg subcutaneous maintenance dose were similar to ARIA rates reported in patients who continued with the IV dose after 18 months and are similar to the background rates of ARIA in patients without treatment. ARIA is usually asymptomatic, although serious and life-threatening events can occur. ARIA can be fatal. Most ARIA with LEQEMBI occurs within the first 6 months of IV initiation treatment. Importance of Ongoing TreatmentAD is a progressive, relentless disease with amyloid beta (Aβ) and tau as hallmarks, caused by a continuous underlying neurotoxic process that begins before amyloid plaque removal and continues afterward(1,2,3). Only LEQEMBI fights AD in two ways – targeting both amyloid plaque and protofibrils*, which can impact tau downstream. Due to the reaccumulation of AD biomarkers and return to placebo rate of decline after therapy is stopped(4,5), maintenance treatment with once-weekly SC injection or once every four weeks of IV therapy offers patients options to continue slowing the disease progression and prolong the benefit of therapy, with the goal of helping patients maintain who they are for longer.In the Clarity AD core study, the mean change from baseline between the lecanemab IV once every 2 weeks treated group and the placebo group after 18 months was -0.45 (P=0.00005) on the primary endpoint of CDR-SB global cognitive and functional scale.To provide context, a change from 0.5 to 1 on the Clinical Dementia Rating (CDR) score domains of Memory, Community Affairs and Home/Hobbies reflects a shift from mild impairment to loss of independence. This can affect a person's ability to be left alone safely, recall recent events, participate in daily activities, manage household tasks, and engage in hobbies and intellectual interests(6,7).** At 48 months of treatment through the Clarity AD core study and its OLE, data showed lecanemab demonstrated a reduction in cognitive decline measured by CDR-SB of -1.75 points compared to the expected decline observed in the Alzheimer's Disease Neuroimaging Initiative (ADNI)*2 cohort.Similarly, when benchmarked against the expected decline in the BioFINDER*3 cohort, lecanemab showed a reduction of -2.17 points measured by CDR-SB at the four-year mark.Importance of SC Maintenance OptionTo confirm the safe and effective use of LEQEMBI IQLIK in the expected use environments, additional studies were conducted, including a human factors (HF) study*4 and a tolerability assessment of the device. From the perspective of patients and care partners, benefits included the ability to use the device at home, shortening treatment time and to continue treatment without having to worry about visiting an infusion center. Healthcare providers reported that the device has the potential to provide a new option for patients who are responding well to LEQEMBI and should continue treatment. The SC formulation also has the potential to reduce healthcare resources associated with IV maintenance dosing, such as preparation for infusion and nurse monitoring, while increasing infusion capacity for new eligible patients to begin initiation treatment and streamlining the overall AD treatment pathway.Patient Support ProgramsEisai is committed to ensuring that appropriate patients have access to LEQEMBI. In the U.S. Eisai offersseveral support programs to help patients and care partners. Dedicated Patient Navigators will work directlywith patients and families to navigate treatment and coverage for eligible and appropriate patients and to helpwith what to expect regarding insurance coverage, co-pay and patient access programs. Injection support willalso be available for LEQEMBI IQLIK patients. To learn more visit LEQEMBI.com, call 1-833-4-LEQEMBI (1-833-453-7362), Monday-Friday, 8 a.m. to 8 p.m. Eastern Time.In addition, to support access to LEQEMBI for certain patients who need help paying for their medicines, Eisai’s Patient Assistance Program (PAP) will provide LEQEMBI and LEQEMBI IQLIK at no cost, for eligible uninsured and underinsured patients, including Medicare beneficiaries, who meet financial need and other program criteria.LEQEMBI IQLIK will be launched on October 6, 2025 in the U.S. Click here to learn about how LEQEMBIIQLIK offers patient-centric early Alzheimer's care and our U.S. Pricing Approach.Eisai serves as the lead for lecanemab’s development and regulatory submissions globally with Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision-making authority. For more details, please visit: https://www.eisai.com/news/2025/pdf/enews202559pdf.pdf  Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO, Japan, August 29, 2025 - (JCN Newswire via SeaPRwire.com) – Honda Motor Co., Ltd. (Honda) today announced new plans regarding the relocation of its global head office function:1) Honda will relocate its global head office function, before the end of 2029*, to the high-rise office floors of a new mixed-use building currently under construction near Tokyo Station, as a part of the Yaesu 2-Chome Central District Category-I Urban Redevelopment Project (“Yaesu District Redevelopment Area”).2) Honda will conduct a partial transfer of the ownership of Honda Aoyama Building (“Aoyama Bldg.”), the company’s existing head office building in Aoyama, Minato-ku, Tokyo, to Mitsui Fudosan Residential Co., Ltd.Yaesu 2-Chome Central District Category-I Urban Redevelopment ProjectPerspective drawing of exterior (Tokyo Station Yaesu Exit side)It has been 40 years since Honda built the Aoyama Bldg. as its global head office. Amid the continued rapid transformation of society and industry, Honda continues striving to be a “company society wants to exist” into the future. To fulfill this vision, Honda has been carefully considering various approaches to establish a global head office function that will serve as a “hub for transformation and communication that fosters innovation.” In September 2023, Honda decided to proceed with the plan to reconstruct Aoyama Bldg. into a new building, which will enable Honda to realize this vision, with target completion in the fiscal year ending March 31, 2031.The fountainhead of Honda innovations has been the “Waigaya (Y-gaya)” process, a unique communication culture of Honda, in which individual associates transcend their respective roles and positions, and engage in vigorous exchanges of their opinions that yields higher results. Since the temporary relocation of the head office function to Toranomon in Tokyo in May, Honda has been adopting a “one-floor” style of office layout, with associates working in one space on one floor, instead of spread across multiple floors. It has become evident that this office layout has strengthened connections among associates and facilitated more diverse members to come together and engage in more dynamic Waigaya discussions, which has begun generating ideas for a wide range of future innovations. In light of these factors, Honda reconsidered the optimal office conditions for its new global head office, and came to the conclusion that it is the best to relocate its head office to the Yaesu District Redevelopment Area, which includes the former site of the Honda Yaesu Building where the Honda global head office was located from 1960 to 1974. When relocated to the Yaesu District Redevelopment Area, the size of each office floor will be approximately 6.8 times larger than that of the Aoyama Bldg. and approximately 1.8 times larger compared to the current office in Toranomon, whereby Honda will strive to achieve significant enhancement in productivity and new value creation.For Honda, Yaesu is a place of special significance, as it was the location of the first operation base where the company strived to establish a presence in Tokyo, began taking on challenges to become a global brand, and laid the foundation for what Honda has become today. Moreover, the Yaesu District has been considered one of the world’s most renowned business districts, serving as a hub for cutting-edge technology and information, with its proximity to Tokyo Station providing excellent access both domestically and internationally. Currently, redevelopment projects are underway across the district, and further enhancement of urban city functions and services is expected in the future.Regarding the Aoyama Bldg., after thorough consideration of the traditional Honda approach to building design as well as the current business environment surrounding Honda, the company decided to transfer a portion of its ownership of the building and land of Aoyama Bldg. to Mitsui Fudosan Residential. The site of Aoyama Bldg. served as the second global head office building owned by Honda in Tokyo for approximately 40 years since 1985, and also housed Honda Welcome Plaza Aoyama to invite the public to see and experience Honda products and technologies, and it will remain a place of deep significance for Honda. Following the partial transfer, Honda and Mitsui Fudosan Residential will jointly construct a new building on the site of Aoyama Bldg. Once completed, Honda is planning to make use of part of the new building, and will explore a range of ideas and opportunities to make it a venue to further enhance Honda brand value.Honda global head office relocation schedule- May 2025 — Honda head office functions relocated temporarily to offices in Toranomon Alcea Tower and Honda Wako Building. - Before the end of 2029* — Honda head office functions will be relocated permanently on high-rise office floors of the new building in Yaesu District Redevelopment AreaOverview of Yaesu 2-Chome Central District Category-I Urban Redevelopment ProjectProject nameYaesu 2-Chome Central District Category-I Urban Redevelopment ProjectBuilderYaesu 2-Chome Central District Urban Redevelopment Project AssociationLocation4, 5, 6 and 7, Yaesu 2-Chome, Chuo-ku, Tokyo, JapanCompletionJanuary 31, 2029 (planned)Number of floors/ max height43 floors above ground, 3 floors below ground, approx. 744 ft. (approx. 227 m)Site areaApprox. 210,542 ft2(approx. 19,560 m2)Total floor areaApprox. 4,190,282 ft2(approx. 389,290 m2)Main purposesOffices, retail facilities, theater, serviced apartments, international school, bus terminal, parking lot, etc.ReferenceMitsui Fudosan Group news release:Yaesu 2-Chome Central District Category-I Urban Redevelopment Project:Partial Transfer of Rights to Honda and Joint Reconstruction of Honda Aoyama BuildingURL:  https://www.mitsuifudosan.co.jp/english/corporate/news/2025/0829_01/* Planned completion schedule as of August 2025. The schedule is subject to change in the future.  Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO, August 29, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) announced today that it has received orphan drug designation for anticancer agent the EZH2*1 inhibitor tazemetostat hydrobromide (generic name, product name “Tazverik® Tablets 200 mg”, “tazemetostat”) for unresectable INI1*2-negative epithelioid sarcoma that has progressed after chemotherapy, from the Ministry of Health, Labour and Welfare (MHLW).Epithelioid sarcoma is a type of soft tissue sarcoma that is a rare cancer estimated to account for about 1% of all soft tissue sarcoma.1 Only 174 cases were registered from major hospitals across Japan over a10-year period from 2006 to 2015.2 Loss of INI1, which is a negative regulator of EZH2, is observed in over 90% of epithelioid sarcoma cases,3 leading to EZH2 activation that is believed to drive tumor onset and malignant progression. Treatment options are limited, resulting in an extremely high unmet medical need.Tazemetostat was approved in Japan in June 2021 for relapsed or refractory EZH2 gene mutation-positive follicular lymphoma (only when standard treatment is not applicable). For INI1-negative unresectable epithelioid sarcoma that has progressed after chemotherapy, a Phase II investigator-initiated trial of tazemetostat (A Phase II Trial of Tazemetostat for Patients with Unresectable or Metastatic Epithelioid Sarcoma: TAZETTA trial), led by the National Cancer Center Hospital, is currently underway.Eisai identifies oncology as one of its priority areas and strives to develop ground breaking new therapies aimed at curing cancer. We remain committed to meeting the diverse needs of cancer patients worldwide, their families, and healthcare professionals, and to enhancing the benefits delivered to them.*1 A type of histone methyl group elongation enzyme, it is a protein that controls gene expression by methylating the 27th lysine residue of histone H3 (H3K27).*2 One of the proteins that make up the SWI/SNF chromatin complex (a protein complex that modifies chromatinstructure to regulate gene function), it is involved in regulating gene expression.For more details, please visit: https://www.eisai.com/news/2025/pdf/enews202558pdf.pdfMedia Inquiries:Public Relations Department,Eisai Co., Ltd.+81-(0)3-3817-5120   Copyright 2025 JCN Newswire via SeaPRwire.com.

Completion of strategic acquisition affirms Hitachi Energy’s position as a market and technology leader in advancing energy storage innovation - a cornerstone of secure energy transitionsPower electronics with advanced digital capabilities are critical to ensure reliability and stability of the electric gridZurich, Switzerland, August 28, 2025 - (JCN Newswire via SeaPRwire.com) - Hitachi Energy, a global leader in electrification, has completed the acquisition of the remaining stake in eks Energy, a technology and market leader in power electronics and control solutions to deliver a scalable, flexible, and complete approach for energy storage customers. Hitachi Energy acquired a majority stake in eks Energy in 2023. As energy storage emerges as a cornerstone of grid stability, reliability and energy security, the IEA1 has called for a sixfold increase in global storage capacity to 1,500 GW by 2030. Underscoring this urgency, the COP29 Global Pledge2 highlights energy storage and grid infrastructure as essential to building resilient, decarbonized energy systems worldwide.The integration of eks Energy’s innovative technology, talent and enterprising spirit provides Hitachi Energy with greater strategic and operational flexibility. It allows the company to streamline solution integration, further expand its power conversion and energy storage business, and respond rapidly to evolving customer needs.“As the worldwide market leader in grid automation solutions, the acquisition of eks Energy strengthens our leadership position, enabling one of the industry’s most comprehensive solution portfolios that combines proven converter and control technology with Hitachi Energy’s global scale, unparalleled grid expertise, and digital capabilities,” said Massimo Danieli, Managing Director of Hitachi Energy’s Business Unit Grid Automation. “The acquisition furthers our global strategy ensuring continuity for existing customers while unlocking new opportunities for innovation and growth.”Since 2023, the team has strengthened capabilities for power conversion solutions, including the development of a center of excellence in Seville, Spain, where the business is headquartered, to foster deeper collaboration across R&D, product development, and customer delivery. Additionally, Hitachi Energy’s power conversion solutions business has demonstrated strong commercial momentum and technical leadership across the globe, playing a key role in major energy storage projects such as the Waratah Super Battery in New South Wales, which recently reached key milestones including commercial operation (COD) and full registration under the System Integrity Protection Scheme (SIPS), a fast-acting grid support system designed to maintain stability during critical events. The business has also expanded its global footprint, positioning Hitachi Energy to better serve energy storage customers across key global markets. The successful development and launch earlier this year of a new liquid-cooled WD4 converter platform further enhances performance and scalability across BESS applications for system integrators.Power converters play a critical role connecting power source with power supply, making sure that currents and voltage are balanced correctly for end user demand. They are data-intensive systems, and when paired with Hitachi Energy’s internet of things (IoT) connectivity and energy management capabilities, deliver rich insights and analytics to maximize reliable energy supply. The completion of the acquisition will enable Hitachi Energy to innovate faster and improve the technology at this critical grid connection point.Hitachi Energy is making unparalleled investments in its global footprint and people, continuously pioneering technologies to enable the world’s energy system to be more sustainable, secure, resilient and acquisitions are playing a critical role in supporting the company’s broader strategy. 1 Outlook for battery demand and supply – Batteries and Secure Energy Transitions – Analysis - IEA2 COP29 Global Energy Storage and Grids PledgeAbout Hitachi EnergyHitachi Energy is a global technology leader in electrification, powering a sustainable energy future with innovative power grid technologies with digital at the core. Over three billion people depend on our technologies to power their daily lives. With over a century in pioneering mission-critical technologies like high-voltage, transformers, automation, and power electronics, we are addressing the most urgent energy challenge of our time – balancing soaring electricity demand, while decarbonizing the power system. With an unparalleled installed base in over 140 countries, we co-create and build long-term partnerships across the utility, industry, transportation, data centers, and infrastructure sectors. Headquartered in Switzerland, we employ over 50,000 people in 60 countries and generate revenues of around $16 billion USD.Https://www.hitachienergy.comhttps://www.linkedin.com/company/hitachienergyhttps://x.com/HitachiEnergyAbout Hitachi, Ltd.Through its Social Innovation Business (SIB) that brings together IT, OT (Operational Technology) and products, Hitachi contributes to a harmonized society where the environment, wellbeing, and economic growth are inbalance. Hitachi operates globally in four sectors – Digital Systems & Hitachi Energy is a global technology leader in electrification, powering a sustainable energy future with innovative power grid technologies with digital at the core. Over three billion people depend on our technologies to power their daily lives. Services, Energy, Mobility, and Connective Industries – and the Strategic SIB Business Unit for new growth businesses. With Lumada at its core, Hitachi generates value from integrating data, technology and domain knowledge to solve customer and social challenges. Revenues for FY2024 (ended March 31, 2025) totaled 9,783.3 billion yen, with 618 consolidated subsidiaries and approximately 280,000 employees worldwide. Visit us at www.hitachi.com.  Copyright 2025 JCN Newswire via SeaPRwire.com.